ArticleNucleic acids research2018
Histone H2A variants confer specific properties to nucleosomes and impact on chromatin accessibility.
Article in Nucleic acids research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 97 citations in OpenAlex.
- H2AC19 promotes lung adenocarcinoma progressionActa pharmaceutica Sinica. B · 2026Article
- Antagonistic histone H2A variants and autonomous heterochromatin formation shape epigenomic patterns in Arabidopsis.Nature communications · 2026Article
- Replication-independent eviction of the histone variant H2B.8 reveals chromatin reprogramming during seed imbibition.Nature communications · 2026Article
- Histone variant H2A.X represses deposition of active H3K4me3 marks and restricts H2A.W incorporation.Nucleic acids research · 2026Article
- Histone variant H2A.Z cooperates with EBNA1 to maintain Epstein-Barr virus latent epigenome.mBio · 2025Article
- Histone variant H2A.W7 represses meiotic crossover formation inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- DDM1 Maintains Heterochromatin by Regulating Histone Variants.International journal of molecular sciences · 2025Review
- The histone variant H2A.W restricts heterochromatic crossovers inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- An Oryza-specific histone H4 variant predisposes H4 lysine 5 acetylation to modulate salt stress responses.Nature plants · 2025Article
- Article
- PTGS is dispensable for the initiation of epigenetic silencing of an active transposon in Arabidopsis.EMBO reports · 2024Article
- Molecular and structural basis of the chromatin remodeling activity by Arabidopsis DDM1.Nature communications · 2024Article
- Mind the gap: Epigenetic regulation of chromatin accessibility in plants.Plant physiology · 2024Review
- In vitro co-expression chromatin assembly and remodeling platform for plant histone variants.Scientific reports · 2024Article
- The chromatin source-sink hypothesis: a shared mode of chromatin-mediated regulations.Development (Cambridge, England) · 2023Article
- Article
- Arabidopsis histone H3 lysine 9 methyltransferases KYP/SUVH5/6 are involved in leaf development by interacting with AS1-AS2 to repress KNAT1 and KNAT2.Communications biology · 2023Article
- Seminars in cell and development biology on histone variants remodelers of H2A variants associated with heterochromatin.Seminars in cell & developmental biology · 2023Review
- Contribution of the histone variant H2A.Z to expression of responsive genes in plants.Seminars in cell & developmental biology · 2023Review
- A New Set of Golden-Gate-Based Organelle Marker Plasmids for Colocalization Studies in Plants.Plants (Basel, Switzerland) · 2022Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
In eukaryotes, variants of core histone H2A are selectively incorporated in distinct functional domains of chromatin and are distinguished by conserved sequences of their C-terminal tail, the L1 loop and the docking domain, suggesting that each variant confers specific properties to the nucleosome. Chromatin of flowering plants contains four types of H2A variants, which biochemical properties have not been characterized. We report that in contrast with animals, in Arabidopsis thaliana H2A variants define only four major types of homotypic nucleosomes containing exclusively H2A, H2A.Z, H2A.X or H2A.W. In vitro assays show that the L1 loop and the docking domain confer distinct stability of the nucleosome. In vivo and in vitro assays suggest that the L1 loop and the docking domain cooperate with the C-terminal tail to regulate chromatin accessibility. Based on these findings we conclude that the type of H2A variant in the nucleosome impacts on its interaction with DNA and propose that H2A variants regulate the dynamics of chromatin accessibility. In plants, the predominance of homotypic nucleosomes with specific physical properties and their specific localization to distinct domains suggest that H2A variants play a dominant role in chromatin dynamics and function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.