Evidence map›Paper›PMID 29944914›Full record

ArticleFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association2018

Arsenic-induced apoptosis in the p53-proficient and p53-deficient cells through differential modulation of NFkB pathway.

Lei Yin, Xiaozhong Yu

Abstract read
In one paragraph

Article in Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  11. Coenzyme QBMC pharmacology & toxicology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lei YinDepartment of Environmental Health Science, College of Public Health, University of Georgia, 150 Green Street, Athens, GA 30602, USA. Fax: 706.542.7472; ReproTox Biotech LLC, 111 Riverbend Drive, Athens, Georgia, United States. Electronic address: lei@uga.edu.
Xiaozhong YuDepartment of Environmental Health Science, College of Public Health, University of Georgia, 150 Green Street, Athens, GA 30602, USA. Fax: 706.542.7472. Electronic address: yuxz@uga.edu.
University of Georgia · US

Funding

Three-dimensional testicular cell co-culture model for reproductive toxicity screeningR44ES027374 · NIEHS · REPROTOX BIOTECH, LLC · PI YIN, LEI · 2018 to 2019
$1.5M
Innovative three-dimensional testicular Co-culture (Mini-Testis) model for reproductive toxicity testing: a pathway based High throughput (HT) and High Content Analysis (HCA)R43ES027374 · NIEHS · REPROTOX BIOTECH, LLC · PI YIN, LEI · 2016 to 2016
$202k
NIEHS NIH HHS R43 ES027374NIEHS NIH HHS R44 ES027374
6 · The paper itself

Abstract

Arsenic is a well-known environmental carcinogen and an effective chemotherapeutic agent. The underlying mechanism of this dual-effect, however, is not fully understood. In this study, we applied mouse p53

Indexed as

AnimalsApoptosisArsenicCells, CulturedCytokinesGene Expression ProfilingGene Regulatory NetworksGenotypeInflammation MediatorsMice, Inbred C57BLMitogen-Activated Protein KinasesNF-kappa BTranscription FactorsTumor Suppressor Protein p53ArsenicCytokinesInflammation MediatorsMitogen-Activated Protein KinasesNF-kappa BTranscription FactorsTumor Suppressor Protein p53Apoptosis and transcription factorsArseniteGene expression profilingNFκBp53

Identifiers

PMID29944914
PMCPMC6689409
OpenAlexW2809988456

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.