ArticlePhysiology & behavior2018
Modulation of learning and memory by the genetic disruption of circadian oscillator populations.
Article in Physiology & behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Cellular- and systems-level profiling of amyloid-beta effects on circadian timing.Neurobiology of disease · 2026Article
- Cellular- and systems-level profiling of amyloid-beta effects on circadian timing.bioRxiv : the preprint server for biology · 2025Article
- Circadian neurogenetics and its implications in neurophysiology, behavior, and chronomedicine.Neuroscience and biobehavioral reviews · 2024Review
- Bmal1 haploinsufficiency impairs fear memory and modulates neuroinflammation via the 5-HT2C receptor.Frontiers in pharmacology · 2024Article
- The Devastating Effects of Sleep Deprivation on Memory: Lessons from Rodent Models.Clocks & sleep · 2023Review
- Neural function of Bmal1: an overview.Cell & bioscience · 2023Review
- Circadian disruption of memory consolidation inFrontiers in systems neuroscience · 2023Article
- Diurnal rhythm regulates the frequency of carbachol-induced beta oscillation via inhibitory neural system in rat hippocampus.Cognitive neurodynamics · 2022Article
- Circadian disruption of hippocampus in an early senescence male mouse model.Pharmacology, biochemistry, and behavior · 2022Article
- Circadian clocks, cognition, and Alzheimer's disease: synaptic mechanisms, signaling effectors, and chronotherapeutics.Molecular neurodegeneration · 2022Review
- Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer's disease.Acta pharmaceutica Sinica. B · 2022Review
- Circadian rhythms as modulators of brain health during development and throughout aging.Frontiers in neural circuits · 2022Review
- Bmal1 in the striatum influences alcohol intake in a sexually dimorphic manner.Communications biology · 2021Article
- Dysregulated clock gene expression and abnormal diurnal regulation of hippocampal inhibitory transmission and spatial memory in amyloid precursor protein transgenic mice.Neurobiology of disease · 2021Article
- The role of clock genes in sleep, stress and memory.Biochemical pharmacology · 2021Review
- Time-of-day as a critical biological variable.Neuroscience and biobehavioral reviews · 2021Review
- Translating around the clock: Multi-level regulation of post-transcriptional processes by the circadian clock.Cellular signalling · 2021Review
- Spatio-temporal heterogeneity in hippocampal metabolism in control and epilepsy conditions.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Regulation of Olfactory Associative Memory by the Circadian Clock Output Signal Pigment-Dispersing Factor (PDF).The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Circadian regulation of membrane physiology in neural oscillators throughout the brain.The European journal of neuroscience · 2020Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
While a rich literature has documented that the efficiency of learning and memory varies across circadian time, a close survey of that literature reveals extensive heterogeneity in the time of day (TOD) when peak cognitive performance occurs. Moreover, most previous experiments in rodents have not focused on the question of discriminating which memory processes (e.g., working memory, memory acquisition, or retrieval) are modulated by the TOD. Here, we use assays of contextual fear conditioning and spontaneous alternation in WT (C57Bl/6 J) mice to survey circadian modulation of hippocampal-dependent memory at multiple timescales - including working memory (seconds to a few minutes), intermediate-term memory (a delay of thirty minutes), and acquisition and retrieval of long-term memory (a delay of two days). Further, in order to test the relative contributions of circadian timing mechanisms to the modulation of memory, a parallel set of studies were performed in mice lacking clock timing mechanisms. These transgenic mice lacked the essential circadian gene Bmal1, either globally (Bmal1 null) or locally (floxed Bmal1 mice, which lack Bmal1 in excitatory forebrain neurons, e.g. cortical and hippocampal neurons). Here, we show that in WT mice, retrieval (but not working memory, intermediate-term memory, or acquisition of long-term memory) is modulated by TOD. However, transgenic mouse models lacking Bmal1 - both globally, and only in forebrain excitatory neurons - show deficits regardless of the memory process tested (and lack circadian modulation of retrieval). These results provide new clarity regarding the impact of the TOD on hippocampal-dependent memory and support the key role of hippocampal and cortical circadian oscillations in circadian gating of cognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.