Evidence map›Paper›PMID 29944754›Full record

ReviewImmunological reviews2018

iReceptor: A platform for querying and analyzing antibody/B-cell and T-cell receptor repertoire data across federated repositories.

Brian D Corrie, Nishanth Marthandan, Bojan Zimonja, Jerome Jaglale, Yang Zhou, Emily Barr, Nicole Knoetze, Frances M W Breden, Scott Christley, Jamie K Scott and 2 more

Abstract readReview
In one paragraph

Review in Immunological reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Revised Adaptive Immune Receptor Data in the Immune Epitope Database.bioRxiv : the preprint server for biology · 2026
    Article
  7. Article
  8. High-throughput, quantitative approach to peptide epitope discovery.Medical & biological engineering & computing · 2026
    Article
  9. AI-Driven BCR Modeling for Precision Immunology.International journal of molecular sciences · 2026
    Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Machine learning in AIRR diagnostics: Advances and applications.Immunoinformatics (Amsterdam, Netherlands) · 2025
    Article
  20. Article

52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Brian D CorrieThe IRMACS Centre, Simon Fraser University, Burnaby, BC, Canada.ORCID 0000-0003-3888-6495
Nishanth MarthandanThe IRMACS Centre, Simon Fraser University, Burnaby, BC, Canada.
Bojan ZimonjaThe IRMACS Centre, Simon Fraser University, Burnaby, BC, Canada.
Jerome JaglaleThe IRMACS Centre, Simon Fraser University, Burnaby, BC, Canada.
Yang ZhouThe IRMACS Centre, Simon Fraser University, Burnaby, BC, Canada.
Emily BarrThe IRMACS Centre, Simon Fraser University, Burnaby, BC, Canada.
Nicole KnoetzeThe IRMACS Centre, Simon Fraser University, Burnaby, BC, Canada.ORCID 0000-0001-8712-1566
Frances M W BredenThe IRMACS Centre, Simon Fraser University, Burnaby, BC, Canada.
Scott ChristleyDepartment of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Jamie K ScottDeptartment of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada.
Lindsay G CowellDepartment of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-1617-8244
Felix BredenThe IRMACS Centre, Simon Fraser University, Burnaby, BC, Canada.ORCID 0000-0001-9762-6314

Funding

RepServer: Antigen Receptor Repertoire Analysis Pipelines via the WWWR01AI097403 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI COWELL, LINDSAY G. · 2012 to 2016
$3.2M
NIAID NIH HHS R01 AI097403
6 · The paper itself

Abstract

Next-generation sequencing allows the characterization of the adaptive immune receptor repertoire (AIRR) in exquisite detail. These large-scale AIRR-seq data sets have rapidly become critical to vaccine development, understanding the immune response in autoimmune and infectious disease, and monitoring novel therapeutics against cancer. However, at present there is no easy way to compare these AIRR-seq data sets across studies and institutions. The ability to combine and compare information for different disease conditions will greatly enhance the value of AIRR-seq data for improving biomedical research and patient care. The iReceptor Data Integration Platform (gateway.ireceptor.org) provides one implementation of the AIRR Data Commons envisioned by the AIRR Community (airr-community.org), an initiative that is developing protocols to facilitate sharing and comparing AIRR-seq data. The iReceptor Scientific Gateway links distributed (federated) AIRR-seq repositories, allowing sequence searches or metadata queries across multiple studies at multiple institutions, returning sets of sequences fulfilling specific criteria. We present a review of the development of iReceptor, and how it fits in with the general trend toward sharing genomic and health data, and the development of standards for describing and reporting AIRR-seq data. Researchers interested in integrating their repositories of AIRR-seq data into the iReceptor Platform are invited to contact support@ireceptor.org.

Indexed as

Databases, GeneticAntibodiesGenomicsHigh-Throughput Nucleotide SequencingHumansInformation DisseminationInternetReceptors, Antigen, B-CellReceptors, Antigen, T-CellAntibodiesReceptors, Antigen, B-CellReceptors, Antigen, T-Cellcancer immunotherapydata sharingdistributed data federationimmune repertoirestherapeutic antibodiesvaccines

Identifiers

PMID29944754
PMCPMC6344122

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.