Evidence map›Paper›PMID 29944716›Full record

ArticlePloS one2018

Biocompatibility and antibacterial properties of zirconium nitride coating on titanium abutments: An in vitro study.

Giulia Brunello, Paola Brun, Chiara Gardin, Letizia Ferroni, Eriberto Bressan, Roberto Meneghello, Barbara Zavan, Stefano Sivolella

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
8.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 92 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Giulia BrunelloDepartment of Management and Engineering, University of Padova, Vicenza, Italy.ORCID 0000-0003-1436-0085
Paola BrunDepartment of Molecular Medicine, University of Padova, Padova, Italy.
Chiara GardinDepartment of Biomedical Sciences, University of Padova, Padova, Italy.
Letizia FerroniDepartment of Biomedical Sciences, University of Padova, Padova, Italy.
Eriberto BressanDepartment of Neurosciences, Section of Dentistry, University of Padova, Padova, Italy.
Roberto MeneghelloDepartment of Management and Engineering, University of Padova, Vicenza, Italy.
Barbara ZavanDepartment of Biomedical Sciences, University of Padova, Padova, Italy.
Stefano SivolellaDepartment of Neurosciences, Section of Dentistry, University of Padova, Padova, Italy.
University of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Improving soft tissue attachment and reducing bacterial colonization on titanium abutments are key factors for the long-term maintenance of healthy soft and hard peri-implant tissues. This in vitro study was conducted to compare the biocompatibility and antibacterial activity of four different surfaces: uncoated Ti6Al4V, anodized, and coated with titanium nitride or zirconium nitride. Surface topography was investigated with a high-resolution system for measuring surface finishes. Human gingival fibroblast (HGF) adhesion and proliferation were examined using MTT assay, Scanning Electron Microscopy (SEM) imaging, immunofluorescence analysis and real-time PCR for selected target genes. The hemolysis and AMES tests were performed to assess the chemical compounds' blood compatibility and mutagenic potential, respectively. Antibacterial activity was tested against five bacterial strains isolated from the oral cavity (Streptococcus salivarius, S. sanguinis, S. mutans, S. sobrinus, S. oralis), and the percentage of dead bacteria was calculated. Roughness measurements confirmed a substantial similarity between the surfaces and their compatibility with clinical applications. MTT assay, SEM analysis and immunofluorescence staining showed adhesion and proliferation of HGFs cultured on all the examined surfaces. PCR confirmed that HGFs produced extracellular matrix components efficiently on all the surfaces. No hemolytic activity was detected, and the AMES test confirmed the surfaces' clinical safety. For all tested bacterial strains, biofilms grown on the zirconium nitride surface showed a higher percentage of dead bacteria than on the other disks. The titanium nitride surface inactivated bacterial biofilms, too, but to a lesser extent.

Indexed as

Coated Materials, BiocompatibleTitaniumZirconiumAlloysAnti-Bacterial AgentsBiofilmsCell AdhesionCell ProliferationCells, CulturedDental AbutmentsFibroblastsGingivaHumansMaterials TestingStreptococcusSurface PropertiesAlloysAnti-Bacterial AgentsCoated Materials, BiocompatibleTitaniumtitanium alloy (TiAl6V4)titanium nitrideZirconiumzirconium nitride

Identifiers

PMID29944716
PMCPMC6019405
OpenAlexW2811103945

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.