ArticlePloS one2018
Pneumococcal carriage and serotype distribution among children with and without pneumonia in Mozambique, 2014-2016.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed.
- Article
- Urine bioassay optimisation to assess the association between antimicrobial exposure, pneumococcal carriage and antimicrobial resistance among hospitalised children in Malawi.BMC infectious diseases · 2025Article
- Identification of age-group reservoirs for persistent vaccine-type pneumococcal carriage in rural Gambia.Pneumonia (Nathan Qld.) · 2025Article
- Inference of Pairwise Interactions from Strain Frequency Data Across Settings and Context-Dependent Mutual Invasibilities.Bulletin of mathematical biology · 2025Article
- Article
- Article
- Nasopharyngeal Carriage of Streptococcus pneumoniae Serotypes Among Healthy Children in Northern India.Current microbiology · 2022Article
- Pneumococcal concentration and serotype distribution in preschool children with radiologically confirmed pneumonia compared to healthy controls prior to introduction of pneumococcal vaccination in Zanzibar: an observational study.BMC infectious diseases · 2022Observational
- Trends in Asymptomatic NasopharyngealMicroorganisms · 2022Article
- Systematic review and meta-analysis on the etiology of bacterial pneumonia in children in sub-Saharan Africa.Journal of public health in Africa · 2022Article
- Bacteria and viruses in the upper respiratory tract of Congolese children with radiologically confirmed pneumonia.BMC infectious diseases · 2021Article
- Article
- Observational
- Article
- Pharyngeal Carriage of Beta-HaemolyticTropical medicine and infectious disease · 2020Article
- Dried blood spots for Streptococcus pneumoniae and Haemophilus influenzae detection and serotyping among children < 5 years old in rural Mozambique.BMC pediatrics · 2020Article
- High residual carriage of vaccine-serotype Streptococcus pneumoniae after introduction of pneumococcal conjugate vaccine in Malawi.Nature communications · 2020Observational
- High bacterial and viral load in the upper respiratory tract of children in the Democratic Republic of the Congo.PloS one · 2020Article
- Pneumococcal Carriage, Serotype Distribution, and Risk Factors in Children With Community-Acquired Pneumonia, 5 Years After Introduction of the 10-Valent Pneumococcal Conjugate Vaccine in Ethiopia.Open forum infectious diseases · 2019Article
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10 authors.
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Abstract
backgroundPneumococcal colonization is a precursor to pneumonia, and pneumococcal conjugate vaccines (PCV) can decrease vaccine-type (VT) colonization. Pneumococcal colonization studies are traditionally done among healthy children in the community; however, VT colonization prevalence may differ between these children and those with pneumonia. We assessed overall and VT pneumococcal colonization and factors associated with colonization among children with and without pneumonia after Mozambique introduced 10-valent PCV (PCV10) in 2013.
methodsWe used data from ongoing pneumonia surveillance in children aged <5 years and from cross-sectional nasopharyngeal colonization surveys conducted in October 2014 -April 2015 and October 2015 -May 2016. Pneumonia was defined using WHO standard criteria for radiologically confirmed pneumonia. Children with pneumonia enrolled from January 2014 -April 2016 were compared to children without pneumonia enrolled from the cross-sectional surveys. Clinical data and nasopharyngeal (NP) swabs were collected from each child. NP specimens were cultured for pneumococci, and culture-negative specimens from children with pneumonia underwent polymerase chain reaction (PCR).
resultsOf 778 and 927 children with and without pneumonia, 97.4% and 27.0% were exposed to antibiotics before swab collection, respectively. Based on culture, pneumococcal colonization was 45.1% for children with and 84.5% for children without pneumonia (P<0.001); VT pneumococcal colonization was 18.6% for children with and 23.4% for children without pneumonia (P = 0.02). The addition of PCR in children with pneumonia increased overall and VT-pneumococcal colonization to 79.2% and 31.1%, respectively. In multivariable analysis including PCR results, pneumonia was associated with VT pneumococcal colonization (adjusted OR: 1.4, 95%CI: 1.10-1.78).
conclusionVaccine-type pneumococcal colonization remains common among children with and without pneumonia post-PCV10 introduction in Mozambique. In a population of children with high antibiotic exposure, the use of PCR for culture-negative NP swabs can improve assessment of pneumococcal colonization and circulating serotypes.
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