Evidence map›Paper›PMID 29944474›Full record

ArticleAlzheimer disease and associated disorders

Relationships Between Cognitive Complaints and Quality of Life in Older Adults With Mild Cognitive Impairment, Mild Alzheimer Disease Dementia, and Normal Cognition.

Shana D Stites, Kristin Harkins, Jonathan D Rubright, Jason Karlawish

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer disease and associated disorders. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 6 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 6 syntheses or guidelines pooled it, 158 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Effects ofFrontiers in nutrition · 2026
    Trial
  8. Trial
  9. Trial
  10. Trial
  11. Quality of life in a high-risk group of elderly primary care patients: characteristics and potential for improvement.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024
    Trial
  12. Trial
  13. Trial
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Shana D StitesDepartment of Medical Ethics and Health Policy, Perlman School of Medicine.
Kristin HarkinsDepartments of Medicine.
Jonathan D RubrightNational Board of Medical Examiners, Philadelphia, PA.
Jason KarlawishMedicine, Medical Ethics and Health Policy, and Neurology, Penn Memory Center, University of Pennsylvania.
Institute of Medical Ethics · GBNational Board of Medical Examiners · USUniversity of Pennsylvania · US

Funding

UPenn ADCC Biomarker CoreP30AG010124 · NIA · UNIVERSITY OF PENNSYLVANIA · PI XIE, SHARON XIANGWEN · 1991 to 2020
$35.1M
ACL HHS U48DP005053NIA NIH HHS P30 AG010124
6 · The paper itself

Abstract

purposeTo examine in persons with varying degrees of cognitive impairment the relationship between self-reports of cognitive complaints and quality of life (QOL).

methodsOlder adults (n=259) with normal cognition, mild cognitive impairment (MCI), and mild stage Alzheimer disease (AD) dementia completed tests of cognition and self-report questionnaires about QOL and 3 kinds of cognitive complaints: cognitive difficulties, distress from cognitive difficulties, and believing you had more memory problems than most people. Bivariate, multivariable, and multivariate regression analyses assessed relationships between domains of QOL and each cognitive complaint.

resultsBivariate and multivariable analyses controlling for severity of cognitive and functional impairment found that cognitive complaints were related to relatively lower quality of daily life (QOL-AD, Dementia Quality of Life Scale), greater depression (GDS), more anxiety (BAI), higher perceived stress (PSS), and lower general mental well-being (SF-12 MCS). DISCUSSION: Cognitive complaints have robust associations with QOL. These findings have implications for AD prevention trials and management of clinical populations.

Indexed as

Self ReportAgedAlzheimer DiseaseCognitionCognitive DysfunctionFemaleHumansMaleNeuropsychological TestsQuality of LifeSurveys and Questionnaires

Identifiers

PMID29944474
PMCPMC6249095
OpenAlexW2810983525

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.