ArticleAmerican journal of physiology. Endocrinology and metabolism2018
Leptin regulation of core body temperature involves mechanisms independent of the thyroid axis.
Article in American journal of physiology. Endocrinology and metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Weight loss by sodium-glucose co-transporter 2 inhibitor canagliflozin is followed by rebound in db/db mice but maintained in fat-fed mice via circadian rises in body temperature and locomotor activity.The journal of physiological sciences : JPS · 2026Article
- Seasonal metabolic and growth responses of grazing beef heifers divergent in residual feed intake.PloS one · 2026Article
- Thermally induced neuronal plasticity in the hypothalamus mediates heat tolerance.Nature neuroscience · 2025Article
- Review
- Mammalian tumor-like organs. 2. Mammalian adipose has many tumor features and obesity is a tumor-like process.Infectious agents and cancer · 2022Review
- Roles of leptin on energy balance and thermoregulation inFrontiers in physiology · 2022Article
- Leptin Improves Parameters of Brown Adipose Tissue Thermogenesis in Lipodystrophic Mice.Nutrients · 2021Article
- Behavioral, metabolic, and renal outcomes of 1-month isolation in adolescent male Dahl salt-sensitive rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Article
- Leptin: Is It Thermogenic?Endocrine reviews · 2020Review
- Fibroblast Growth Factor-21, Leptin, and Adiponectin Responses to Acute Cold-Induced Brown Adipose Tissue Activation.The Journal of clinical endocrinology and metabolism · 2020Article
- Rats that are predisposed to excessive obesity show reduced (leptin-induced) thermoregulation even in the preobese state.Physiological reports · 2019Article
- Validation of an equation for energy expenditure that does not require the respiratory quotient.PloS one · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The ability to maintain core temperature within a narrow range despite rapid and dramatic changes in environmental temperature is essential for the survival of free-living mammals, and growing evidence implicates an important role for the hormone leptin. Given that thyroid hormone plays a major role in thermogenesis and that circulating thyroid hormone levels are reduced in leptin-deficient states (an effect partially restored by leptin replacement), we sought to determine the extent to which leptin's role in thermogenesis is mediated by raising thyroid hormone levels. To this end, we 1) quantified the effect of physiological leptin replacement on circulating levels of thyroid hormone in leptin-deficient ob/ob mice, and 2) determined if the effect of leptin to prevent the fall in core temperature in these animals during cold exposure is mimicked by administration of a physiological replacement dose of triiodothyronine (T
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.