Evidence map›Paper›PMID 29943902›Full record

Observational studyESC heart failure2018

A novel cardiac output response to stress test developed to improve diagnosis and monitoring of heart failure in primary care.

Sarah J Charman, Nduka C Okwose, Renae J Stefanetti, Kristian Bailey, Jane Skinner, Arsen Ristic, Petar M Seferovic, Mike Scott, Stephen Turley, Ahmet Fuat and 4 more

Erratum issuedAbstract readObservational Study
In one paragraph

Observational study in ESC heart failure, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Corrigendum.ESC heart failure · 2019
    Article
  6. Article
  7. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Sarah J CharmanCardiovascular Research Centre, Institutes of Cellular and Genetic Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Nduka C OkwoseCardiovascular Research Centre, Institutes of Cellular and Genetic Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Renae J StefanettiWellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, Medical School, Newcastle University, Newcastle upon Tyne, UK.
Kristian BaileyRoyal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Jane SkinnerRoyal Victoria Infirmary, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Arsen RisticCardiology Department, Clinical Centre Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia.
Petar M SeferovicCardiology Department, Clinical Centre Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia.
Mike ScottNewburn Surgery, Newcastle upon Tyne, UK.
Stephen TurleyRoseworth Surgery, Newcastle upon Tyne, UK.
Ahmet FuatDarlington Memorial Hospital, County Durham and Darlington NHS Foundation Trust and School of Medicine, Pharmacy and Health, Durham University, Durham, UK.
Jonathan MantPrimary Care Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Richard F D HobbsNuffield Department of Primary Health Care Sciences, University of Oxford, Oxford, UK.
Guy A MacGowanCardiovascular Research Centre, Institutes of Cellular and Genetic Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Djordje G JakovljevicCardiovascular Research Centre, Institutes of Cellular and Genetic Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

Funding

Department of Health IS-SPC-0514-10043Medical Research Council BH161161Medical Research Council MC_PC_11004Medical Research Council MC_PC_15030Medical Research Council MR/L016354/1
6 · The paper itself

Abstract

aimsPrimary care physicians lack access to an objective cardiac function test. This study for the first time describes a novel cardiac output response to stress (CORS) test developed to improve diagnosis and monitoring of heart failure in primary care and investigates its reproducibility. METHODS AND

resultsProspective observational study recruited 32 consecutive primary care patients (age, 63 ± 9 years; female, n = 18). Cardiac output was measured continuously using the bioreactance method in supine and standing positions and during two 3 min stages of a step-exercise protocol (10 and 15 steps per minute) using a 15 cm height bench. The CORS test was performed on two occasions, i.e. Test 1 and Test 2. There was no significant difference between repeated measures of cardiac output and stroke volume at supine standing and Stage 1 and Stage 2 step exercises (all P > 0.3). There was a significant positive relationship between Test 1 and Test 2 cardiac outputs (r = 0.92, P = 0.01 with coefficient of variation of 7.1%). The mean difference in cardiac output (with upper and lower limits of agreement) between Test 1 and Test 2 was 0.1 (-1.9 to 2.1) L/min, combining supine, standing, and step-exercise data.

conclusionsThe CORS, as a novel test for objective evaluation of cardiac function, demonstrates acceptable reproducibility and can potentially be implemented in primary care.

Indexed as

Monitoring, PhysiologicAgedAged, 80 and overCardiac OutputExerciseExercise TestFemaleHeart FailureHumansMaleMiddle AgedPrimary Health CarePrognosisProspective StudiesReproducibility of ResultsCardiac outputDiagnosisGeneral practiceHeart failurePrimary careReproducibilityTest

Identifiers

PMID29943902
PMCPMC6073030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.