Evidence map›Paper›PMID 29943892›Full record

ArticleJournal of applied clinical medical physics2018

Using 4DCT-ventilation to characterize lung function changes for pediatric patients getting thoracic radiotherapy.

Yevgeniy Vinogradskiy, Austin Faught, Richard Castillo, Edward Castillo, Thomas Guerrero, Moyed Miften, Arthur K Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied clinical medical physics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Development and validation of an AI-based lung lobe auto-contouring tool using radiation therapy planning free-breathing images.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2025
    Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Yevgeniy VinogradskiyDepartment of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO, USA.
Austin FaughtDepartment of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO, USA.
Richard CastilloDepartment of Radiation Oncology, Emory University, Atlanta, GA, USA.
Edward CastilloDepartment of Radiation Oncology, Beaumont Health System, Royal Oak, MI, USA.
Thomas GuerreroDepartment of Radiation Oncology, Beaumont Health System, Royal Oak, MI, USA.
Moyed MiftenDepartment of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO, USA.
Arthur K LiuDepartment of Radiation Oncology, University of Colorado School of Medicine, Aurora, CO, USA.
University of Colorado Denver · USBeaumont Health · USEmory University · US

Funding

Clinical trial personalizing radiation therapy through a novel lung function imaging modalityR01CA200817 · NCI · UNIVERSITY OF COLORADO DENVER · PI VINOGRADSKIY, YEVGENIY · 2016 to 2018
$618k
NCI NIH HHS R01 CA200817
6 · The paper itself

Abstract

purposeA form of lung functional imaging has been developed that uses 4DCT data to calculate ventilation (4DCT-ventilation). Because 4DCTs are acquired as standard-of-care to manage breathing motion during radiotherapy, 4DCT-ventilation provides functional information at no extra dosimetric or monetary cost. 4DCT-ventilation has yet to be described in children. 4DCT-ventilation can be used as a tool to help assess post-treatment lung function and predict for future clinical thoracic toxicities for pediatric patients receiving radiotherapy to the chest. The purpose of this work was to perform a preliminary evaluation of 4DCT-ventilation-based lung function changes for pediatric patients receiving radiotherapy to the lungs.

methodsThe study used four patients with pre and postradiotherapy 4DCTs. The 4DCTs, deformable image registration, and a density-change-based algorithm were used to compute pre and post-treatment 4DCT-ventilation images. The post-treatment 4DCT-ventilation images were compared to the pretreatment 4DCT-ventilation images for a global lung response and for an intrapatient dose-response (providing an assessment for dose-dependent regional dose-response).

resultsFor three of the four patients, a global ventilation decline of 7-37% was observed, while one patient did not demonstrate a global functional decline. Dose-response analysis did not reveal an intrapatient dose-response from 0 to 20 Gy for three patients while one patient demonstrated increased 4DCT-ventilation decline as a function of increasing lung doses up to 50 Gy.

conclusionsCompared to adults, pediatric patients have unique lung function, dosimetric, and toxicity profiles. The presented work is the first to evaluate spatial lung function changes in pediatric patients using 4DCT-ventilation and showed lung function changes for three of the four patients. The early changes demonstrated with lung function imaging warrant further longitudinal work to determine whether the imaging-based early changes can be predicted for long-term clinical toxicity.

Indexed as

AdolescentChildFour-Dimensional Computed TomographyHumansLungLung NeoplasmsPulmonary VentilationRadiotherapy Planning, Computer-AssistedRespirationCT ventilationdose--response assessmentlung function imagingpediatric radiotherapy

Identifiers

PMID29943892
PMCPMC6123142
OpenAlexW2811242877

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.