Evidence map›Paper›PMID 29943823›Full record

ArticleJournal of cellular physiology2018

BMAL1 and CLOCK proteins in regulating UVB-induced apoptosis and DNA damage responses in human keratinocytes.

Yang Sun, Peiling Wang, Hongyu Li, Jun Dai

Abstract read
In one paragraph

Article in Journal of cellular physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. The Influence of Circadian Rhythms on DNA Damage Repair in Skin Photoaging.International journal of molecular sciences · 2024
    Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Heptapeptide Isolated fromMarine drugs · 2021
    Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Circadian Clocks and Cancer: Timekeeping Governs Cellular Metabolism.Trends in endocrinology and metabolism: TEM · 2019
    Review
  19. Circadian effects on UV-induced damage and mutations.Mutation research. Reviews in mutation research
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Yang SunSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China.
Peiling WangSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China.
Hongyu LiSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China.
Jun DaiSchool of Pharmaceutical Science and Technology, Tianjin University, Tianjin, China.ORCID 0000-0002-9243-3350
Tianjin University · CNUniversity of Wisconsin–Madison · US

Funding

Growth/differentiation control of keratinocytes by ROR alphaK01AR062132 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI DAI, JUN · 2012 to 2015
$442k
NIAMS NIH HHS K01 AR062132
6 · The paper itself

Abstract

A diverse array of biological processes are under circadian controls. In mouse skin, ultraviolet ray (UVR)-induced apoptosis and DNA damage responses are time-of-day dependent, which are controlled by core clock proteins. This study investigates the roles of clock proteins in regulating UVB responses in human keratinocytes (HKCs). We found that the messenger RNA expression of brain and muscle ARNT-like 1 (BMAL1) and circadian locomotor output cycles kaput (CLOCK) genes is altered by low doses (5 mJ/cm

Indexed as

DNA DamageUltraviolet RaysApoptosisARNTL Transcription FactorsCell DifferentiationCell LineCell ProliferationCLOCK ProteinsDose-Response Relationship, RadiationGene Expression RegulationHistonesHumansKeratinocytesARNTL Transcription FactorsBMAL1 protein, humanCLOCK protein, humanCLOCK ProteinsH2AX protein, humanHistonesapoptosisbrain and muscle ARNT-like 1 (BMAL1)clockDNA damagekeratinocytesultraviolet B (UVB)

Identifiers

PMID29943823
PMCPMC6185778
OpenAlexW2810235826

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.