Evidence map›Paper›PMID 29943729›Full record

ArticleeLife2018

Optogenetic dissection of descending behavioral control in

Jessica Cande, Shigehiro Namiki, Jirui Qiu, Wyatt Korff, Gwyneth M Card, Joshua W Shaevitz, David L Stern, Gordon J Berman

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 1 pooled it
8.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 1 synthesis or guideline pooled it, 179 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Inhibitory control explains locomotor statistics in walkingProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. The fruit fly,Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  13. Article
  14. Gradients of Cell Recognition Molecules Wire Visuomotor Transformation.bioRxiv : the preprint server for biology · 2025
    Article
  15. Inhibitory control of locomotor statistics in walkingbioRxiv : the preprint server for biology · 2024
    Article
  16. Article
  17. Comparative connectomics of the descending and ascending neurons of thebioRxiv : the preprint server for biology · 2024
    Article
  18. Article
  19. Article
  20. Article

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Jessica CandeJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
Shigehiro NamikiJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID http://orcid.org/0000-0003-1559-799X
Jirui QiuDepartment of Physics, Emory University, Atlanta, Georgia.
Wyatt KorffJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID http://orcid.org/0000-0001-8396-1533
Gwyneth M CardJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID http://orcid.org/0000-0002-7679-3639
Joshua W ShaevitzThe Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, United States.
David L SternJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID http://orcid.org/0000-0002-1847-6483
Gordon J BermanDepartment of Physics, Emory University, Atlanta, Georgia.ORCID https://orcid.org/0000-0003-3588-7820
Howard Hughes Medical Institute · USEmory University · USPrinceton University · US

Funding

A new paradigm for quantifying animal behavior in a model genetic systemR01GM098090 · NIGMS · PRINCETON UNIVERSITY · PI BIALEK, WILLIAM, SHAEVITZ, JOSHUA W · 2011 to 2014
$1.6M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM098090NIH HHS GM09809
6 · The paper itself

Abstract

In most animals, the brain makes behavioral decisions that are transmitted by descending neurons to the nerve cord circuitry that produces behaviors. In insects, only a few descending neurons have been associated with specific behaviors. To explore how descending neurons control an insect's movements, we developed a novel method to systematically assay the behavioral effects of activating individual neurons on freely behaving terrestrial

Indexed as

AnimalsBehavior, AnimalBiological AssayBrainBrain MappingDrosophila melanogasterDrosophila ProteinsEfferent PathwaysGenes, ReporterLocomotionNeuronsOptogeneticsSpatial BehaviorTranscription FactorsDrosophila ProteinsGAL4 protein, DrosophilaTranscription Factorsbehaviordescending interneuronsD. melanogasterneuroscienceoptogenetics

Identifiers

PMID29943729
PMCPMC6031430
OpenAlexW2783823892

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.