Trial reportThe American journal of tropical medicine and hygiene2018
Safety, Immunogenicity, and Protective Efficacy against Controlled Human Malaria Infection of
Open access · greenAbstract readRandomized Controlled Trial
In one paragraph
Trial report in The American journal of tropical medicine and hygiene, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 3 pooled it
18.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
95 citing papers in PubMed, 3 syntheses or guidelines pooled it, 164 citations in OpenAlex.
- A systematic review on malaria and Tuberculosis (TB) vaccine challenges in sub-Saharan African clinical trials.PloS one · 2025Pooled it
- Pooled it
- Reproducibility of malaria sporozoite challenge model in humans for evaluating efficacy of vaccines and drugs: a systematic review.BMC infectious diseases · 2021Pooled it
- Safety, tolerability and immunogenicity of a condensed, multi-dose prime regimen of PfSPZ Vaccine for the prevention of Plasmodium falciparum malaria infection.Malaria journal · 2025Trial
- Innate immune activation restricts priming and protective efficacy of the radiation-attenuated PfSPZ malaria vaccine.JCI insight · 2024Trial
- Safety and protective efficacy of PfSPZ Vaccine administered to HIV-negative and -positive Tanzanian adults.The Journal of clinical investigation · 2024Trial
- Safety and Immunogenicity of Radiation-Attenuated PfSPZ Vaccine in Equatoguinean Infants, Children, and Adults.The American journal of tropical medicine and hygiene · 2023Trial
- A randomized controlled trial showing safety and efficacy of a whole sporozoite vaccine against endemic malaria.Science translational medicine · 2022Trial
- Trial
- Safety, immunogenicity and efficacy of PfSPZ Vaccine against malaria in infants in western Kenya: a double-blind, randomized, placebo-controlled phase 2 trial.Nature medicine · 2021Trial
- Trial
- Increase of Dose Associated With Decrease in Protection Against Controlled Human Malaria Infection by PfSPZ Vaccine in Tanzanian Adults.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Trial
- Safety, Tolerability, and Immunogenicity of Plasmodium falciparum Sporozoite Vaccine Administered by Direct Venous Inoculation to Infants and Young Children: Findings From an Age De-escalation, Dose-Escalation, Double-blind, Randomized Controlled Study in Western Kenya.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Trial
- Safety and Differential Antibody and T-Cell Responses to theThe American journal of tropical medicine and hygiene · 2019Trial
- Cytotoxic Vδ2+ T cell subsets expand in response to malaria in human tonsil and spleen organoids.PLoS pathogens · 2026Article
- The endemic dilemma: why whole sporozoite malaria vaccine efficacy falls in the field.Trends in parasitology · 2026Review
- Dysfunctional memory B cell responses to the protective repeat region of thebioRxiv : the preprint server for biology · 2025Article
- Successful insertion and expression of a tetracycline transactivator in Anopheles stephensi associated with increased egg production and decreased hatching rate.Parasites & vectors · 2025Article
- The path from early- to late-liver stage arresting genetically attenuated parasites as a malaria vaccination strategy.NPJ vaccines · 2025Review
- Tanzanian gut microbiota profiles linked to high but rapidly waning yellow fever antibody titers.NPJ biofilms and microbiomes · 2025Article
35 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
33 authors at 5 institutions in 3 countries.
Said A JongoBagamoyo Research and Training Centre, Ifakara Health Institute, Bagamoyo, Tanzania.
Seif A ShekalagheBagamoyo Research and Training Centre, Ifakara Health Institute, Bagamoyo, Tanzania.
L W Preston ChurchSanaria Inc., Rockville, Maryland.
Adam J RubenSanaria Inc., Rockville, Maryland.
Tobias SchindlerUniversity of Basel, Basel, Switzerland.
Isabelle ZenklusenUniversity of Basel, Basel, Switzerland.
Tobias RutishauserUniversity of Basel, Basel, Switzerland.
Julian RothenUniversity of Basel, Basel, Switzerland.
Anneth TumboBagamoyo Research and Training Centre, Ifakara Health Institute, Bagamoyo, Tanzania.
Catherine MkindiBagamoyo Research and Training Centre, Ifakara Health Institute, Bagamoyo, Tanzania.
Maximillian MpinaBagamoyo Research and Training Centre, Ifakara Health Institute, Bagamoyo, Tanzania.
Ali T MtoroBagamoyo Research and Training Centre, Ifakara Health Institute, Bagamoyo, Tanzania.
Andrew S IshizukaVaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Kamaka Ramadhani KassimBagamoyo Research and Training Centre, Ifakara Health Institute, Bagamoyo, Tanzania.
Florence A MilandoBagamoyo Research and Training Centre, Ifakara Health Institute, Bagamoyo, Tanzania.
Munira QassimBagamoyo Research and Training Centre, Ifakara Health Institute, Bagamoyo, Tanzania.
Omar A JumaBagamoyo Research and Training Centre, Ifakara Health Institute, Bagamoyo, Tanzania.
Solomon MwakasungulaBagamoyo Research and Training Centre, Ifakara Health Institute, Bagamoyo, Tanzania.
Beatus SimonBagamoyo Research and Training Centre, Ifakara Health Institute, Bagamoyo, Tanzania.
Eric R JamesSanaria Inc., Rockville, Maryland.
Yonas AbebeSanaria Inc., Rockville, Maryland.
Natasha KcSanaria Inc., Rockville, Maryland.
Sumana ChakravartySanaria Inc., Rockville, Maryland.
Elizabeth SaverinoSanaria Inc., Rockville, Maryland.
Bakari M BakariBagamoyo Research and Training Centre, Ifakara Health Institute, Bagamoyo, Tanzania.
Peter F BillingsleySanaria Inc., Rockville, Maryland.
Robert A SederVaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Claudia DaubenbergerUniversity of Basel, Basel, Switzerland.
B Kim Lee SimProtein Potential LLC, Rockville, Maryland.
Thomas L RichieSanaria Inc., Rockville, Maryland.
Marcel TannerUniversity of Basel, Basel, Switzerland.
Salim AbdullaBagamoyo Research and Training Centre, Ifakara Health Institute, Bagamoyo, Tanzania.
Stephen L HoffmanSanaria Inc., Rockville, Maryland.
Ifakara Health Institute · TZSanaria · USSwiss Tropical and Public Health Institute · CHNational Institute of Allergy and Infectious Diseases · USUniversity of Basel · CH
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007171 · NIGMS · DUKE UNIVERSITY · PI KONTOS, CHRISTOPHER D · 1985 to 2021
$31.2MDevelopment of Pre-Erythrocytic Malaria Vaccines and antibodiesZIAAI005107 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SEDER, ROBERT A · 2010 to 2025
$20.7MNIGMS NIH HHS T32 GM007171
Abstract
We are using controlled human malaria infection (CHMI) by direct venous inoculation (DVI) of cryopreserved, infectious
Indexed as
Immunogenicity, VaccineAdministration, IntravenousAdultDouble-Blind MethodHuman ExperimentationHumansImmunizationMalaria, FalciparumMalaria VaccinesMalePlasmodium falciparumSporozoitesTanzaniaYoung AdultMalaria Vaccines
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.