ArticleMacromolecular bioscience2018
A General Strategy for Extrusion Bioprinting of Bio-Macromolecular Bioinks through Alginate-Templated Dual-Stage Crosslinking.
Article in Macromolecular bioscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- In Situ Characterisation of Hydrogels via Dynamic Interface Printing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Bioprinting of Alginate-Norbornene bioinks to create a versatile platform for kidneyBioactive materials · 2025Article
- Integrating microfluidic and bioprinting technologies: advanced strategies for tissue vascularization.Lab on a chip · 2025Review
- Bioprinting vascularized skin analogs: a stepwise approach.Burns & trauma · 2025Review
- Versatile Potential of Photo-Cross-Linkable Silk Fibroin: Roadmap from Chemical Processing Toward Regenerative Medicine and Biofabrication Applications.Biomacromolecules · 2023Review
- Advances in Gelatin Bioinks to Optimize Bioprinted Cell Functions.Advanced healthcare materials · 2023Review
- 3D Bioprinting of Cell-Laden Hydrogels for Improved Biological Functionality.Advanced materials (Deerfield Beach, Fla.) · 2022Review
- Replace and repair: Biomimetic bioprinting for effective muscle engineering.APL bioengineering · 2021Review
- The potential of microfluidics-enhanced extrusion bioprinting.Biomicrofluidics · 2021Article
- Controlling cellular organization in bioprinting through designed 3D microcompartmentalization.Applied physics reviews · 2021Article
- Advances in 3D bioprinting technology for cardiac tissue engineering and regeneration.Bioactive materials · 2021Review
- Recent Advances in 3D Printing with Protein-Based Inks.Progress in polymer science · 2021Article
- 3D bioprinting of hepatocytes: core-shell structured co-cultures with fibroblasts for enhanced functionality.Scientific reports · 2021Article
- Bioinks for 3D Bioprinting: A Scientometric Analysis of Two Decades of Progress.International journal of bioprinting · 2021Article
- Photo-Crosslinked Silk Fibroin for 3D Printing.Polymers · 2020Review
- Rheological Properties of Coordinated Physical Gelation and Chemical Crosslinking in Gelatin Methacryloyl (GelMA) Hydrogels.Macromolecular bioscience · 2020Article
- Expanding and optimizing 3D bioprinting capabilities using complementary network bioinks.Science advances · 2020Article
- Extrusion and Microfluidic-based Bioprinting to Fabricate Biomimetic Tissues and Organs.Advanced materials technologies · 2020Article
- Additive Biomanufacturing with Collagen Inks.Bioengineering (Basel, Switzerland) · 2020Review
- Advanced gelatin-based vascularization bioinks for extrusion-based bioprinting of vascularized bone equivalents.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The recently developed 3D bioprinting technology has greatly improved the ability to generate biomimetic tissues that are structurally and functionally relevant to their human counterparts. The selection of proper biomaterials as the bioinks is a key step toward successful bioprinting. For example, viscosity of a bioink is an important rheological parameter to determine the flexibility in deposition of free-standing structures and the maintenance of architectural integrity following bioprinting. This requirement, however, has greatly limited the selection of bioinks, especially for those naturally derived due to their commonly low mechanical properties. Here the generalization of a mechanism for extrusion bioprinting of bio-macromolecular components, mainly focusing on collagen and its derivatives including gelatin and gelatin methacryloyl, is reported. Specifically, a templating strategy is adopted using a composite bioink containing both the desired bio-macromolecular component and a polysaccharide alginate. The physically crosslinkable alginate component serves as the temporal structural support to stabilize the shape of the construct during bioprinting; upon subsequent chemical or physical crosslinking of the bio-macromolecular component, alginate can be selectively removed to leave only the desired bio-macromolecule. It is anticipated that this strategy is general, and can be readily expanded for use of a wide variety of other bio-macromolecular bioinks.
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Registered trials
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