ArticleClinical oral investigations2019
The antimicrobial properties, cytotoxicity, and differentiation potential of double antibiotic intracanal medicaments loaded into hydrogel system.
Article in Clinical oral investigations, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Antibacterial and biocompatibility properties of bioactive glass and double antibiotic-loaded hydrogels in regenerative endodontic treatment.Scientific reports · 2025Article
- Managing a Complicated Crown Fracture of a Central Incisor: A Case Report With 1-Year Follow-Up.Clinical case reports · 2025Article
- Environmental stimuli-responsive hydrogels in endodontics: Advances and perspectives.International endodontic journal · 2025Review
- Local drug delivery for regeneration and disinfection in endodontics: A narrative review.Journal of conservative dentistry and endodontics · 2025Review
- Cytotoxicity of Different Concentrations of Silver Nanoparticles and Calcium Hydroxide for MC3T3-E1 Preosteoblast Cell Line.Clinical and experimental dental research · 2025Article
- Effect of finisher Gentlefile Brush, XP-Endo Finisher and Passive Ultrasonic Irrigation in removing radiopaque double antibiotic paste from the root canal.Bioinformation · 2025Article
- Cytocompatibility and Antibiofilm Activity of Calcium Hydroxide Mixed withAntibiotics (Basel, Switzerland) · 2024Article
- Article
- Comparison of Antibacterial Efficacy of Triple Antibiotic-Loaded Hydrogel Versus Modified Triple Antibiotic-Loaded Hydrogel as Intracanal Medicament Against Enterococcus faecalis: An In vitro Study.European endodontic journal · 2024Article
- A prospective case series in regenerative endodontics: The effective use of diluted antibiotic hydrogels in endodontic regeneration procedures.The Saudi dental journal · 2023Article
- The antimicrobial efficacy of nanographene oxide and double antibiotic paste per se and in combination: part II.BMC oral health · 2023Article
- Regenerative endodontic therapy in mature teeth with necrotic pulp and apical periodontitis using two disinfection protocols.BMC oral health · 2023Article
- Use of a Cellulase fromPharmaceutics · 2023Article
- Effect of Different Intracanal Medicaments on the Viability and Survival of Dental Pulp Stem Cells.Journal of personalized medicine · 2022Article
- Regenerative Endodontics and Minimally Invasive Dentistry: Intertwining Paths Crossing Over Into Clinical Translation.Frontiers in bioengineering and biotechnology · 2022Review
- Effect of Hydrogel-Based Antibiotic Intracanal Medicaments on Push-Out Bond Strength.European journal of dentistry · 2020Article
- The Effects of Intracanal Irrigants and Medicaments on Dental-Derived Stem Cells Fate in Regenerative Endodontics: An update.Stem cell reviews and reports · 2020Review
- Pivotal Local Drug Delivery Systems in Endodontics; A Review of Literature.Iranian endodontic journal · 2020Review
- Antibacterial efficacy of antibiotic pastes versus calcium hydroxide intracanal dressing: A systematic review and meta-analysis ofJournal of conservative dentistry : JCDReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study evaluated the antimicrobial properties, cytotoxicity, and mineralization potential of methylcellulose hydrogels loaded with low concentrations of double antibiotic pastes (DAP). MATERIALS AND
methodsThe direct and residual antibacterial effects of 1, 5, and 10 mg/mL of DAP loaded into hydrogels as well as calcium hydroxide (Ca(OH)
resultsAll tested concentrations of DAP hydrogels as well as Ca(OH)
conclusionsHydrogels containing 1 mg/mL DAP offered significant direct antibacterial effects against single- and dual-species biofilms without causing significant negative effects on viability, ALP activity, and mineralization nodule formation of DPSC. CLINICAL RELEVANCE: The methylcellulose-based hydrogel proposed in this study can be used clinically as a biocompatible system to deliver controlled low concentrations of DAP.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.