Trial reportClinical research in cardiology : official journal of the German Cardiac Society2019
Long-term effects of device-guided slow breathing in stable heart failure patients with reduced ejection fraction.
Trial report in Clinical research in cardiology : official journal of the German Cardiac Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Comparison of diaphragmatic breathing exercises and incentive spirometry on the functional status of heart failure patients: a randomized controlled trial.BMC cardiovascular disorders · 2025Trial
- Eight weeks of device-guided slow breathing decreases sympathetic nervous reactivity to stress in posttraumatic stress disorder.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Trial
- The autonomic nervous system in the regulation of glucose and lipid metabolism.Nature reviews. Endocrinology · 2026Review
- Effect of breathing exercises on blood pressure and heart rate: A systematic review and meta-analysis.International journal of cardiology. Cardiovascular risk and prevention · 2024Article
- Improved exercise ventilatory efficiency with nasal compared to oral breathing in cardiac patients.Frontiers in physiology · 2024Article
- Existing Meditation and Breathing Devices for Stress Reduction and Their Incorporated Stimuli: A Systematic Literature Review and Competition Analysis.Mayo Clinic proceedings. Digital health · 2023Review
- Induced Relaxation Enhances the Cardiorespiratory Dynamics in COVID-19 Survivors.Entropy (Basel, Switzerland) · 2023Article
- Breathing pattern and pulmonary gas exchange in elderly patients with and without left ventricular dysfunction-modification with exercise-based cardiac rehabilitation and prognostic value.Frontiers in cardiovascular medicine · 2023Article
- Reducing Test Anxiety by Device-Guided Breathing: A Pilot Study.Frontiers in psychology · 2022Article
- Coupling between Blood Pressure and Subarachnoid Space Width Oscillations during Slow Breathing.Entropy (Basel, Switzerland) · 2021Article
- FIFA World Cup 2018: effect of emotional stress on conventional heart rate variability metrics.Clinical research in cardiology : official journal of the German Cardiac Society · 2020Article
- Slow breathing improves cardiovascular reactivity to mental stress and health-related quality of life in heart failure patients with reduced ejection fraction.Cardiology journal · 2020Article
- Tachycardia: The hidden cardiovascular risk factor in uncomplicated arterial hypertension.Cardiology journal · 2020Review
- Heart rate and blood pressure monitoring in heart failure.European heart journal supplements : journal of the European Society of Cardiology · 2019Article
- Impact of slow breathing on the blood pressure and subarachnoid space width oscillations in humans.Scientific reports · 2019Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSlow breathing (SLOWB) alleviates symptoms of chronic heart failure (HF) but its long-term effects are unknown. We examined the acute and long-term impact of device-guided breathing on hemodynamics and prognostic parameters in HF patients with reduced ejection fraction (HFrEF). METHODS AND
resultsTwenty-one patients with HFrEF (23.9 ± 5.8%, SD ± mean) on optimal medical therapy underwent blood pressure (BP), heart rate (HR), HR variability, 6-min walk test (6MWT), cardiopulmonary exercise testing (CPET), and echocardiography measurements before and 3 months after SLOWB home training (30 min daily). After 3 months, all patients were assigned to continue SLOWB (Group 1) or no-SLOWB (Group 2). All tests were repeated after 6 months. Acute SLOWB (18 ± 5 vs 8 ± 2 breaths/min, P < 0.001) had no influence on BP and HR but improved saturation (97 ± 2 vs 98 ± 2%, P = 0.01). Long-term SLOWB reduced office systolic BP (P < 0.001) but not central or ambulatory systolic BP. SLOWB reduced SDNN/RMSSD ratio (P < 0.05) after 3 months. One-way repeated measures of ANOVA revealed a significant increase in 6MWT and peak RER (respiratory exchange ratio) from baseline to 6-month follow-up in group 1 (P < 0.05) but not group 2 (P = 0.85 for 6MWT, P = 0.69 for RER). No significant changes in echocardiography were noted at follow-up. No HF worsening, rehospitalisation or death occurred in group 1 out to 6-month follow-up. Two hospitalizations for HF decompensation and two deaths ensued in group 2 between 3- and 6-month follow-up.
conclusionsSLOWB training improves cardiorespiratory capacity and appears to slow the progression of HFrEF. Further long-term outcome studies are required to confirm the benefits of paced breathing in HFrEF.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.