ArticleBrain topography2018
Accurate Coil Positioning is Important for Single and Paired Pulse TMS on the Subject Level.
Article in Brain topography, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Transcranial magnetic stimulation-evoked electroencephalography responses as biomarkers for epilepsy: A review of study design and outcomes.Human brain mapping · 2023Pooled it
- Blunted anterior midcingulate response to reward in opioid users is normalized by prefrontal transcranial magnetic stimulation.Translational psychiatry · 2025Trial
- Article
- Coil Orientation in Transcranial Magnetic Stimulation Affects Motor-evoked Potential Size more than its Timing or Waveform Shape.Brain topography · 2026Article
- From Functional Mapping to Functional Recovery: The Emerging Role of Neuronavigated rTMS in Neurorehabilitation.Brain sciences · 2026Review
- Efficient Gaussian process-based motor hotspot hunting with concurrent optimization of TMS coil location and orientation.PLoS computational biology · 2026Article
- Single-pulse transcranial magnetic stimulation of the dorsolateral prefrontal cortex does not directly affect muscle sympathetic nerve activity in humans.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- A 3D-Printed helmet for precise and repeatable neuromodulation targeting in awake non-human primates.Heliyon · 2024Article
- Real-time estimation of the optimal coil placement in transcranial magnetic stimulation using multi-task deep learning.Scientific reports · 2024Article
- Modelling the differential effects of age on transcranial magnetic stimulation induced electric fields.Journal of neural engineering · 2023Article
- Selective Stimulus Intensity during Hotspot Search Ensures Faster and More Accurate Preoperative Motor Mapping with nTMS.Brain sciences · 2023Article
- Reliability of corticospinal excitability and intracortical inhibition in biceps femoris during different contraction modes.The European journal of neuroscience · 2023Article
- Semi-automated motor hotspot search (SAMHS): a framework toward an optimised approach for motor hotspot identification.Frontiers in human neuroscience · 2023Article
- Reliability of transcranial magnetic stimulation and H-reflex measurement during balance perturbation tasks.Frontiers in physiology · 2022Article
- Fast acquisition of resting motor threshold with a stimulus-response curve - Possibility or hazard for transcranial magnetic stimulation applications?Clinical neurophysiology practice · 2022Article
- Development and Validation of a Novel Calibration Methodology and Control Approach for Robot-Aided Transcranial Magnetic Stimulation (TMS).IEEE transactions on bio-medical engineering · 2021Article
- Characterizing off-target corticospinal responses to double-cone transcranial magnetic stimulation.Experimental brain research · 2021Article
- Transcranial Magnetic Stimulation to Assess Exercise-Induced Neuroplasticity.Frontiers in neuroergonomics · 2021Review
- TMS Motor Mapping Methodology and Reliability: A Structured Review.Frontiers in neuroscience · 2021Review
- Local Differences in Cortical Excitability - A Systematic Mapping Study of the TMS-Evoked N100 Component.Frontiers in neuroscience · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Function-guided navigation is commonly used when assessing cortical excitability using transcranial magnetic stimulation (TMS). However, the required accuracy, stability and the effect of a change in coil positioning are not entirely known. This study investigates the accuracy of function-guided navigation for determining the hotspot. Furthermore, it evaluates the effect of a change in coil location on the single and paired pulse excitability measures: motor evoked potential (MEP) amplitude, TMS evoked potential (TEP) and long intracortical inhibition (LICI), and of a change in coil orientation on LICI. Eight healthy subjects participated in the single pulse study, and ten in the paired pulse study. A robot-guided navigation system was used to ensure accurate and stable coil positioning at the motor hotspot as determined using function-guided navigation. In addition, we targeted four locations at 2 mm and four at 5 mm distance around the initially defined hotspot, and we increased and decreased the coil orientation by 10°. In none of the subjects, the largest MEP amplitudes were evoked at the originally determined hotspot, resulting in a poor accuracy of function-guided navigation. At the group level, a change in coil location had no significant effect on the MEP amplitude, TEP, or LICI, and a change in coil orientation did not significantly affected LICI. However, at the subject level significant effects on MEP amplitude, TEP, and LICI were found for changes in coil location or orientation, although absolute differences were relatively small and did not show a consistent pattern. This study indicates that a high accuracy in coil positioning is especially required to measure cortical excitability reliably in individual subjects using single or paired pulse TMS.
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