Evidence map›Paper›PMID 29943239›Full record

Trial reportExperimental brain research2018

The effects of transcranial alternating current stimulation (tACS) at individual alpha peak frequency (iAPF) on motor cortex excitability in young and elderly adults.

Shane Fresnoza, Monica Christova, Theresa Feil, Eugen Gallasch, Christof Körner, Ulrike Zimmer, Anja Ischebeck

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Experimental brain research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.

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  17. Neuromodulation techniques - From non-invasive brain stimulation to deep brain stimulation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Shane FresnozaInstitute of Psychology, University of Graz, Graz, Austria. shane.fresnoza@uni-graz.at.ORCID http://orcid.org/0000-0002-9938-2285
Monica ChristovaOtto Loewi Research Center, Physiology Section, Medical University of Graz, Graz, Austria.
Theresa FeilInstitute of Psychology, University of Graz, Graz, Austria.
Eugen GallaschInstitute of Physiology, Medical University of Graz, Graz, Austria.
Christof KörnerInstitute of Psychology, University of Graz, Graz, Austria.
Ulrike ZimmerInstitute of Psychology, University of Graz, Graz, Austria.
Anja IschebeckInstitute of Psychology, University of Graz, Graz, Austria.
University of Graz · ATFH JOANNEUM University of Applied Sciences · ATMedical University of Graz · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcranial alternating current stimulation (tACS) can modulate brain oscillations, cortical excitability and behaviour. In aging, the decrease in EEG alpha activity (8-12 Hz) in the parieto-occipital and mu rhythm in the motor cortex are correlated with the decline in cognitive and motor functions, respectively. Increasing alpha activity using tACS might therefore improve cognitive and motor function in the elderly. The present study explored the influence of tACS on cortical excitability in young and old healthy adults. We applied tACS at individual alpha peak frequency for 10 min (1.5 mA) to the left motor cortex. Transcranial magnetic stimulation was used to assess the changes in cortical excitability as measured by motor-evoked potentials at rest, before and after stimulation. TACS increased cortical excitability in both groups. However, our results also suggest that the mechanism behind the effects was different, as we observed an increase and decrease in intracortical inhibition in the old group and young group, respectively. Our results indicate that both groups profited similarly from the stimulation. There was no indication that tACS was more effective in conditions of low alpha power, that is, in the elderly.

Indexed as

AdolescentAdultAgedAgingBiophysicsElectroencephalographyElectromyographyEvoked Potentials, MotorFemaleFourier AnalysisHumansMaleMiddle AgedMotor CortexPyramidal TractsSingle-Blind MethodAgingAlpha oscillationElectroencephalogramNeuronal entrainmentTranscranial alternating current stimulationTranscranial magnetic stimulation

Identifiers

PMID29943239
PMCPMC6153871
OpenAlexW2810504669

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.