Evidence map›Paper›PMID 29943236›Full record

ArticleChinese journal of integrative medicine2019

Systems-Based Interactome Analysis for Hematopoiesis Effect of Angelicae sinensis Radix: Regulated Network of Cell Proliferation towards Hemopoiesis.

Guang Zheng, He Zhang, Yun Yang, Ying-Li Sun, Yan-Jing Zhang, Ju-Ping Chen, Ting Hao, Cheng Lu, Hong-Tao Guo, Ge Zhang and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Chinese journal of integrative medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Trial
  2. Traditional Chinese medicine for treating aplastic anemia.Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques · 2023
    Review
  3. TLR Signaling Rescues Fungicidal Activity in Syk-Deficient Neutrophils.Journal of immunology (Baltimore, Md. : 1950) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Guang ZhengInformation Science and Engineering School, Lanzhou University, Lanzhou, 730000, China. forzhengguang@163.com.
He ZhangInformation Science and Engineering School, Lanzhou University, Lanzhou, 730000, China.
Yun YangInformation Science and Engineering School, Lanzhou University, Lanzhou, 730000, China.
Ying-Li SunSchool of Biology, Lanzhou University, Lanzhou, 730000, China.
Yan-Jing ZhangInformation Science and Engineering School, Lanzhou University, Lanzhou, 730000, China.
Ju-Ping ChenInformation Science and Engineering School, Lanzhou University, Lanzhou, 730000, China.
Ting HaoInformation Science and Engineering School, Lanzhou University, Lanzhou, 730000, China.
Cheng LuInstitute of Basic Research in Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
Hong-Tao GuoDepartment of Rheumatism, the First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, 450000, China.
Ge ZhangSchool of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong SAR, China.
Dan-Ping FanInstitute of Basic Research in Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
Xiao-Juan HeInstitute of Basic Research in Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
Ai-Ping LuSchool of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong SAR, China.
Lanzhou University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNHong Kong Baptist University · HKFirst Affiliated Hospital of Henan University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the molecular-level mechanism on the hematopoiesis effect of Angelicae sinensis Radix (ASR) with systems-based interactome analysis.

methodsThis systems-based interactome analysis was designed to enforce the workflow of "ASR (herb)→compound→target protein→internal protein actions→ending regulated protein for hematopoiesis". This workflow was deployed with restrictions on regulated proteins expresses in bone marrow and anemia disease and futher validated with experiments.

resultsThe hematopoiesis mechanism of ASR might be accomplished through regulating pathways of cell proliferation towards hemopoiesis with cross-talking agents of spleen tyrosine kinase (SYK), Janus kinase 2 (JAK2), and interleukin-2-inducible T-cell kinase (ITK). The hematopoietic function of ASR was also validated by colony-forming assay performed on mice bone marrow cells. As a result, SYK, JAK2 and ITK were activated.

conclusionThis study provides a new approach to systematically study and predict the therapeutic mechanism for ASR based on interactome analysis towards biological process with experimental validations.

Indexed as

Angelica sinensisAnimalsBone MarrowCell ProliferationDrugs, Chinese HerbalHematopoiesisJanus Kinase 2MiceMice, Inbred BALB CPlant RootsProtein-Tyrosine KinasesSyk KinaseDrugs, Chinese Herbalemt protein-tyrosine kinaseJak2 protein, mouseJanus Kinase 2Protein-Tyrosine KinasesSyk KinaseSyk protein, mouseAngelicae sinensis Radixcell proliferationcross-talking agentshemopoiesisinteractomeregulation

Identifiers

PMID29943236
OpenAlexW2810280371

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.