ArticleEuropean radiology2019
CT diagnosis of pleural and stromal invasion in malignant subpleural pure ground-glass nodules: an exploratory study.
Article in European radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 56 citations in OpenAlex.
- Habitat-Based Radiomics for Predicting Visceral Pleural Invasion in Subpleural Nodules with Solid Component on Low-Dose CT: A Multicenter Study.Diagnostics (Basel, Switzerland) · 2026Article
- CT predictors of visceral pleural invasion in subsolid nodular pulmonary adenocarcinoma: differences between direct and indirect tumor-pleura contact.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026Observational
- Preoperative CT-based radiomics to predict the 5-year growth of residual nodules after resection of dominant lung tumors in patients with multiple lung subsolid nodules.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025Article
- Predicting Invasiveness of Lung Adenocarcinoma from Chest CT with Few-shot Vision-Language Ternary Classification Model.NPJ digital medicine · 2025Article
- Deep learning and radiomics fusion for predicting the invasiveness of lung adenocarcinoma within ground glass nodules.Scientific reports · 2025Article
- Integrating radiomics features and CT semantic characteristics for predicting visceral pleural invasion in clinical stage Ia peripheral lung adenocarcinoma.Discover oncology · 2025Article
- Clinical TNM Lung Cancer Staging: A Diagnostic Algorithm with a Pictorial Review.Diagnostics (Basel, Switzerland) · 2025Review
- Prediction of visceral pleural invasion of clinical stage IA lung adenocarcinoma based on computed tomography features.Translational cancer research · 2025Article
- Prognostic significance of visceral pleural changes in stage IA lung adenocarcinoma: a retrospective study.Frontiers in oncology · 2025Article
- The value of interlobar fissure semilunar sign based on multifactor joint analysis in predicting the invasiveness of ground glass nodules with interlobar fissure attachment in the lungs.BMC pulmonary medicine · 2024Article
- Baseline computed tomography imaging findings could assist in early diagnosis of visceral pleural invasion for newly discovered early subpleural non-small cell lung cancer: T1 or T2.Journal of thoracic disease · 2024Article
- Intratumoral and peritumoral radiomics combined with computed tomography features for predicting the invasiveness of lung adenocarcinoma presenting as a subpleural ground-glass nodule with a consolidation-to-tumor ratio ≤50.Journal of thoracic disease · 2024Article
- Imaging diagnostics of pulmonary ground-glass nodules: a narrative review with current status and future directions.Quantitative imaging in medicine and surgery · 2024Review
- Nomogram using intratumoral and peritumoral radiomics for the preoperative prediction of visceral pleural invasion in clinical stage IA lung adenocarcinoma.Journal of cardiothoracic surgery · 2024Article
- Research progress in predicting visceral pleural invasion of lung cancer: a narrative review.Translational cancer research · 2024Review
- Construction of a predictive model of 2-3 cm ground-glass nodules developing into invasive lung adenocarcinoma using high-resolution CT.Frontiers in medicine · 2024Article
- Development and validation ofAnnals of nuclear medicine · 2023Article
- Predicting pleural invasion of invasive lung adenocarcinoma in the adjacent pleura by imaging histology.Oncology letters · 2023Article
- Tumour-pleura relationship on CT is a risk factor for occult lymph node metastasis in peripheral clinical stage IA solid adenocarcinoma.European radiology · 2023Article
- Multivariate analysis based on the maximum standard unit value ofDiagnostic and interventional radiology (Ankara, Turkey) · 2023Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo assess the risk of visceral pleural invasion (VPI) and improve the diagnosis of invasive adenocarcinoma (IA) in pure ground-glass nodules (pGGNs) in contact with pleura, through a comprehensive analysis of the thin-section CT features of subpleural malignant pGGNs.
methodsCT findings and clinical information of 115 consecutive patients in our hospital between January 2012 and December 2015 who met the following criteria were retrospectively studied: (a) thin-section CT within 1 month before surgery proved pGGN in contact with pleura, and (b) the pGGN was confirmed as malignancy by surgery. Univariate analysis and a multivariate logistic regression analysis were conducted to identify the independent risk factors of IA and VPI.
resultsNo pleural invasion was observed microscopically in any of the pGGNs. Univariate analysis indicated that tumour shape (p = 0.004), relative density (p = 0.038) and the existence of pleural retraction (p < 0.001) were significantly different between the invasive group and pre- or minimally invasive group. Multivariate logistic regression analysis revealed that pleural retraction (OR, 5.663; p < 0.001), lobulated tumour shape (OR, 4.812; p = 0.016) and tumour relative density greater than 1.60 (OR, 4.449; p = 0.001) were independent risk factors of IA.
conclusionsPulmonary adenocarcinoma manifesting as pGGN generally does not invade the pleura. A comprehensive consideration of tumour shape, relative density and tumour-pleural relationship can independently predict IA. KEY POINTS: • This study showed that pGGN-like adenocarcinoma generally does not invade the pleura. • This study suggested that persistent pGGN with pleural retraction, lobulated shape and high relative density (> 1.60) may very likely be invasive adenocarcinoma. • Using "relative density" can reduce confounding of contrast agent and respiratory status in analysis of CT images.
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