Evidence map›Paper›PMID 29943097›Full record

Trial reportJournal of cancer research and clinical oncology2018

Evaluation of the effects of sensorimotor exercise on physical and psychological parameters in breast cancer patients undergoing neurotoxic chemotherapy.

Paul Lennart Vollmers, Christoph Mundhenke, Nicolai Maass, Dirk Bauerschlag, Stefan Kratzenstein, Christoph Röcken, Thorsten Schmidt

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of cancer research and clinical oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 11 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 11 syntheses or guidelines pooled it.

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  8. The effects of exercise on chemotherapy-induced peripheral neuropathy symptoms in cancer patients: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
    Pooled it
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  11. Exercise for reducing falls in people living with and beyond cancer.The Cochrane database of systematic reviews · 2018
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  12. Lending a hand: supportive exercise therapy for cancer treatment-induced polyneuropathy of the upper extremity-VISCIPH A.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
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  13. Efficacy of combined hand exercise intervention in patients with chemotherapy-induced peripheral neuropathy: a pilot randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Paul Lennart VollmersUniversity Hospital for Women, Arnold-Heller-Straße 3, Haus 24, 24105, Kiel, Germany. vollmersmedien@gmx.de.ORCID http://orcid.org/0000-0002-4407-1842
Christoph MundhenkeUniversity Hospital for Women, Arnold-Heller-Straße 3, Haus 24, 24105, Kiel, Germany.
Nicolai MaassUniversity Hospital for Women, Arnold-Heller-Straße 3, Haus 24, 24105, Kiel, Germany.
Dirk BauerschlagComprehensive Cancer Center North, University of Kiel, Arnold-Heller-Straße 3, Haus 14, 24105, Kiel, Germany.
Stefan KratzensteinInstitute of Sports Psychology, University of Kiel, Olshausenstraße 74, 24118, Kiel, Germany.
Christoph RöckenComprehensive Cancer Center North, University of Kiel, Arnold-Heller-Straße 3, Haus 14, 24105, Kiel, Germany.
Thorsten SchmidtComprehensive Cancer Center North, University of Kiel, Arnold-Heller-Straße 3, Haus 14, 24105, Kiel, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionBreast cancer is the most common cancer disease of women in industrialized countries. Neurotoxic chemotherapy drugs are known to harm peripheral nerves and cause a chemotherapy-induced peripheral neuropathy (CIPN). CIPN is one of the most common adverse events associated with Paclitaxel chemotherapy and may remain present long after the termination of chemotherapy. Thus, it reduces the patients' quality of life (QoL) both during chemotherapy and onwards, and can impose a danger on breast cancer survivors due to an increased risk of falling and fall-related injuries.

methodsThe aim of this randomized-controlled trial (RCT) (n = 36) (IG: intervention group, n = 17) (CG: control group, n = 19) was to determine whether sensorimotor exercises have a positive effect on physical and psychological parameters in breast cancer patients undergoing neurotoxic chemotherapy (Paclitaxel).

resultsAs a result, we were able to show significant improvements in postural stability in monopedal stance [left leg 16.17 ± 3.67 vs. 21.55 ± 5.33 (p < 0.001) and right leg 15.14 ± 2.30 vs. 20.85 ± 5.05 (p < 0.001)] and in bipedal stance [T1 vs. T0, - 0.49 (IG) vs. + 1.14 (CG) p = 0.039]. DISCUSSION: These results in posturography correlate with the clinical presentation with intervention group patients scoring significantly better on the Fullerton Advanced Balance Scale [37.71 ± 2.73 vs. 34.47 ± 3.98 (p = 0.004)]. Moderate strength training successfully prevented a strength loss in the IG that was remarkable in the CG (- 1.60 vs. 0.60, p = 0.029). Concerning the psychological parameters assessed via EORTC- and MFI-questionnaires, no significant improvements were found.

conclusionFuture studies should focus on the correlation of clinical and posturometry findings and subjective QOL such as the long-term-development of CIPN.

Indexed as

AdultAgedAntineoplastic AgentsBreast NeoplasmsCase-Control StudiesExerciseFemaleHumansMiddle AgedPaclitaxelPeripheral Nervous System DiseasesQuality of LifeSensorimotor CortexSurvivorsYoung AdultAntineoplastic AgentsPaclitaxelAdverse eventsBipedal stanceBR-23Breast cancerChair rising testChemotherapyChemotherapy-induced peripheral polyneuropathyCIPN-20EortcEuropean organization of research and treatment of cancerExercise interventionFABFall riskFullterton Advanced Balance ScaleHand dynamometerLower extremityMamma-carcinomaMFI-20Monopedal stanceMultidimensional Fatigue InventoryNervesNeuropathyNeurotoxicPaclitaxelPostural instabilityPosturographyPosturometryQLQ-C30QolQuality of lifeRisk of fallingSensorimotor exerciseStrengthSurvivorsSway areaTaxolTrainingUpper extremity

Identifiers

PMID29943097
PMCPMC11813415

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.