Evidence map›Paper›PMID 29943085›Full record

ArticleCardiovascular toxicology2018

Inhalation of Simulated Smog Atmospheres Affects Cardiac Function in Mice.

Haiyan Tong, Jonathan D Krug, Q Todd Krantz, Charly King, Marie M Hargrove, M Ian Gilmour, Stephen H Gavett

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular toxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Haiyan TongEnvironmental Public Health Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, 109 TW. Alexander Dr., Research Triangle Park, NC, 27711, USA. Tong.haiyan@epa.gov.
Jonathan D KrugExposure Methods and Measurements Division, National Exposure Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC, USA.
Q Todd KrantzEnvironmental Public Health Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, 109 TW. Alexander Dr., Research Triangle Park, NC, 27711, USA.
Charly KingEnvironmental Public Health Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, 109 TW. Alexander Dr., Research Triangle Park, NC, 27711, USA.
Marie M HargroveOak Ridge Institute for Science and Education, Oak Ridge, TN, USA.
M Ian GilmourEnvironmental Public Health Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, 109 TW. Alexander Dr., Research Triangle Park, NC, 27711, USA.
Stephen H GavettEnvironmental Public Health Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, 109 TW. Alexander Dr., Research Triangle Park, NC, 27711, USA.
Environmental Protection Agency · USOak Ridge Institute for Science and EducationResearch Triangle Park Foundation · US

Funding

Intramural EPA EPA999999
6 · The paper itself

Abstract

The health effects of individual criteria air pollutants have been well investigated. However, little is known about the health effects of air pollutant mixtures that more realistically represent environmental exposures. The present study was designed to evaluate the cardiac effects of inhaled simulated smog atmospheres (SA) generated from the photochemistry of either gasoline and isoprene (SA-G) or isoprene (SA-Is) in mice. Four-month-old female mice were exposed for 4 h to filtered air (FA), SA-G, or SA-Is. Immediately and 20 h after exposure, cardiac responses were assessed with a Langendorff preparation using a protocol consisting of 20 min of global ischemia followed by 2 h of reperfusion. Cardiac function was measured by index of left-ventricular developed pressure (LVDP) and cardiac contractility (dP/dt) before ischemia. Pre-ischemic LVDP was lower in mice immediately after SA-Is exposure (52.2 ± 5.7 cm H

Indexed as

Air PollutantsAnimalsButadienesCardiotoxicityCoronary CirculationFemaleGasolineHemiterpenesInhalation ExposureIsolated Heart PreparationMice, Inbred C57BLMyocardial ContractionSmogVentricular Dysfunction, LeftVentricular Function, LeftVentricular PressureAir PollutantsButadienesGasolineHemiterpenesisopreneSmogCardiac contractilityCardiac functionMicePhotochemical reactionSimulated atmospheres

Identifiers

PMID29943085
PMCPMC7303869
OpenAlexW2810465800

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.