ArticleJournal of cell communication and signaling2019
Baicalin attenuates collagen-induced arthritis via inhibition of JAK2-STAT3 signaling and regulation of Th17 cells in mice.
Article in Journal of cell communication and signaling, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Efficacy and safety of nitazoxanide and escitalopram as adjuvant therapies in patients with rheumatoid arthritis: a randomized controlled study.European journal of clinical pharmacology · 2025Trial
- Chemoproteomics identifies STAT3 as a key target of baicalin in ameliorating liver fibrosis.National science review · 2026Article
- Cyclosporine and fedratinib combination therapy via modulating Th17/Treg balance in Rat model of membranous glomerulonephritis.Biochemistry and biophysics reports · 2024Article
- Baicalin reduced injury of and autophagy-related gene expression in RAW264.7 cells infected with H6N6 avian influenza virus.Heliyon · 2024Article
- Danggui Niantong granules ameliorate rheumatoid arthritis by regulating intestinal flora and promoting mitochondrial apoptosis.Pharmaceutical biology · 2022Article
- Scutellaria baicalensis georgi is a promising candidate for the treatment of autoimmune diseases.Frontiers in pharmacology · 2022Review
- Anti-inflammatory effect of baicalin in rats with adjuvant arthritis and its autophagy- related mechanism.Technology and health care : official journal of the European Society for Engineering and Medicine · 2022Article
- Baicalin alleviates collagen‑induced arthritis and suppresses TLR2/MYD88/NF‑κB p65 signaling in rats and HFLS‑RAs.Molecular medicine reports · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study focused on the potential therapeutic effect of Baicalin on collagen-induced arthritis (CIA) in mice and the underlying mechanisms. Baicalin (200 mg/kg) was administrated after the induction of CIA for 42 days. Therapeutic effects were evaluated by arthritic scores, X-rays and assessment of histopathological joint destruction. The production of TNF-α,IL-6,IL-17,IL-1β were also measured. The percentage of Th17 cells in splenocytes were determined by flow cytometry analysis. Our results showed that Baicalin treatment attenuated the severity of arthritis of CIA mice and reduced the levels of several cytokines. Further mechanistic investigations revealed that Baicalin suppressed the expression and phosphorylation of JAK2 and STAT3 protein in splenocytes tissue. Moreover, the percentage of Th17 cells in splenocytes also downregulated by Baicalin. Our experiment indicate that CIA mice can be alleviated by Baicalin treatment via inhibition of JAK2-STAT3 signaling and regulation of Th17 cells in mice.
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Registered trials
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