ArticleInternational journal of reproductive biomedicine2018
Protective effect of cerium oxide nanoparticle on sperm quality and oxidative damage in malathion-induced testicular toxicity in rats: An experimental study.
Article in International journal of reproductive biomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 56 citations in OpenAlex.
- Rare Earth Elements in Testicular Function: Current Knowledge and Future Directions.International journal of molecular sciences · 2026Review
- Nanotechnology for reproductive healthcare: a comprehensive review.Journal of nanobiotechnology · 2026Review
- Management of cardiovascular disease by cerium oxide nanoparticles via alleviating oxidative stress and adipokine abnormalities.Scientific reports · 2025Article
- Potential protective role of chlorogenic acid against cyclophosphamide-induced reproductive damage in male mice.Toxicology research · 2024Article
- Oxidative Stress-Associated Male Infertility: Current Diagnostic and Therapeutic Approaches.Medicina (Kaunas, Lithuania) · 2024Review
- Antioxidant and hypoglycemic potential of phytogenic cerium oxide nanoparticles.Scientific reports · 2023Article
- Protective effect of cerium oxide on testicular function and oxidative stress after torsion/detorsion in adult male rats.Experimental and therapeutic medicine · 2023Article
- Effect of Cerium Oxide Nanoparticles on the Expression of Developmental and Apoptosis Genes of Testicular Tissue in 6-Day-Old NMRI Mice Fetuses.Biological trace element research · 2022Article
- Rifaximin Protects against Malathion-Induced Rat Testicular Toxicity: A Possible Clue on Modulating Gut Microbiome and Inhibition of Oxidative Stress by Mitophagy.Molecules (Basel, Switzerland) · 2022Article
- Predominance of Antioxidants in Some Edible Plant Oils in Ameliorating Oxidative Stress and Testicular Toxicity Induced by Malathion.Life (Basel, Switzerland) · 2022Article
- Effect of Cerium Oxide on Kidney and Lung Tissue in Rats with Testicular Torsion/Detorsion.BioMed research international · 2022Article
- Metal Oxide Nanoparticles: Evidence of Adverse Effects on the Male Reproductive System.International journal of molecular sciences · 2021Review
- Protective role of melatonin against adipose-hepatic metabolic comorbidities in experimentally induced obese rat model.PloS one · 2021Article
- Alleviation of silver nanoparticle-induced sexual behavior and testicular parameters dysfunction in male mice by yttrium oxide nanoparticles.Toxicology reports · 2021Article
- Nanotechnology in reproductive medicine: Opportunities for clinical translation.Clinical and experimental reproductive medicine · 2020Article
- Effect of Cerium Oxide Nanoparticles on Oxidative Stress Biomarkers in Rats' Kidney, Lung, and Serum.Iranian biomedical journal · 2020Article
- Organophosphate toxicity: updates of malathion potential toxic effects in mammals and potential treatments.Environmental science and pollution research international · 2020Review
- The Effect of Chilgoza Pine Nut (Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMalathion is an organophosphorus pesticide that commonly used in many agricultural and non-agricultural processes. Previous studies have reported the effects of melatonin on the reproductive system. Cerium dioxide nanoparticles (CeNPs) due to their antioxidative properties are promising to impact on the development of male infertility.
objectiveThe aim of this study was to evaluate the effect of CeNPs on oxidative stress and sperm parameters after malathion exposure of male rats. MATERIALS AND
methods36 adult male Wistar rats were divided into 6 groups (n=6/each): Control, CeNPs -treated control (15 and 30 mg/kg/day), malathion (100 mg/ kg/day), and CeNPs -treated malathion groups (15 and 30 mg/ kg/day). At the end of the study (4 wk), the sperm counts, motility, and viability in the testis of rats were measured, also lipid peroxidation, total antioxidant capacity, and total thiol groups in homogenate testis were investigated.
resultsMalathion significantly reduced sperm count, viability, and motility than the control rats (p<0.001). Co-treatment of malathion with CeNPs 30 mg/kg had a protective effect on sperm counts (p=0.03), motility (p=0.01), and viability (p<0.001) compare to malathion group. Also, the results showed that malathion reduced testis total anti-oxidant capacity, the total thiol group, and increased testis malondialdehyde than the control rats (p<0.001). CeNPs 30 mg/kg are increased total antioxidant capacity (p<0.001) and total thiol group (p=0.03) compared to malathion group. CeNPs at both doses (15 and 30 mg/kg) improved malondialdehyde than the malathion group (p<0.001 and p=0.01 respectively).
conclusionCeNPs 30 mg/kg administered considerably restored testicular changes induced by malathion. The improvement of oxidative stress by CeNPs may be associated with increased sperm counts, motility and viability in the testis.
Indexed as
Identifiers
29942934PMC6004590W2884211293What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.