ArticleJournal of the Endocrine Society2018
Oral Glucose Tolerance Test Glucose Peak Time Is Most Predictive of Prediabetes and Hepatic Steatosis in Obese Girls.
Article in Journal of the Endocrine Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Two- vs one-hour glucose tolerance testing: Predicting prediabetes in adolescent girls with obesity.Pediatric diabetes · 2019Trial
- Glucose curve morphology and peak time as biomarkers of metabolic health.American journal of physiology. Endocrinology and metabolism · 2026Article
- Association between early-stage diabetic nephropathy and the delayed monophasic glucose peak during oral glucose tolerance test in type 2 diabetes mellitus.Journal of diabetes investigation · 2025Observational
- Article
- Evaluating glucose variability through OGTT in early pregnancy and its association with hypertensive disorders of pregnancy in non-diabetic pregnancies: a large-scale multi-center retrospective study.Diabetology & metabolic syndrome · 2023Article
- Diabetic family history in young Japanese persons with normal glucose tolerance associates with k-means clustering of glucose response to oral glucose load, insulinogenic index and Matsuda index.Metabolism open · 2022Article
- Changes in OGTT-derived biomarkers in response to lifestyle intervention among Latino adolescents with obesity.Pediatric obesity · 2022Article
- Sensory and process optimization of a mango bagasse-based beverage with high fiber content and low glycemic index.Journal of food science and technology · 2022Article
- Mathematical modeling reveals differential dynamics of insulin action models on glycerol and glucose in adolescent girls with obesity.Frontiers in physiology · 2022Article
- Time to the Peak, Shape of the Curve and Combination of These Glucose Response Characteristics During Oral Glucose Tolerance Test as Indicators of Early Beta-cell Dysfunction in Obese AdolescentsJournal of clinical research in pediatric endocrinology · 2021Article
- Oral minimal model-based estimates of insulin sensitivity in obese youth depend on oral glucose tolerance test protocol duration.Metabolism open · 2021Article
- Delayed glucose peak and elevated 1-hour glucose on the oral glucose tolerance test identify youth with cystic fibrosis with lower oral disposition index.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2021Article
- Effects of Combined High-Protein Diet and Exercise Intervention on Cardiometabolic Health in Middle-Aged Obese Adults: A Randomized Controlled Trial.Frontiers in cardiovascular medicine · 2021Article
- Role of exercise on insulin sensitivity and beta-cell function: is exercise sufficient for the prevention of youth-onset type 2 diabetes?Annals of pediatric endocrinology & metabolism · 2020Article
- Review of methods for detecting glycemic disorders.Diabetes research and clinical practice · 2020Review
- Metabolic and Genetic Determinants of Glucose Shape After Oral Challenge in Obese Youths: A Longitudinal Study.The Journal of clinical endocrinology and metabolism · 2020Article
- The Oral Glucose Tolerance Test: 100 Years Later.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Review
- The shape of the glucose response curve during an oral glucose tolerance test heralds β-cell function in a large Chinese population.BMC endocrine disorders · 2019Article
- A simple method to monitor hepatic gluconeogenesis and triglyceride synthesis following oral sugar tolerance test in obese adolescents.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Obese adolescent girls are at increased risk for type 2 diabetes, characterized by defects in insulin secretion and action. We sought to determine if later glucose peak timing (>30 minutes), 1-hour glucose >155 mg/dl, or monophasic pattern of glucose excursion during an oral glucose tolerance test (OGTT) reflect a worse cardiometabolic risk profile. Post-pubertal overweight/obese adolescent girls without diabetes were studied (N = 88; age, 15.2 ± 0.2 years; body mass index percentile, 97.7 ± 0.5). All participants completed an OGTT and body composition measures. Thirty-two girls had a four-phase hyperinsulinemic euglycemic clamp with isotope tracers, vascular imaging, and muscle mitochondrial assessments. Participants were categorized by glucose peak timing (≤30 min = early; >30 min = late), 1-hour glucose concentration (±155 mg/dL) and glucose pattern (monophasic, biphasic). Girls with a late (N = 54) vs earlier peak (n = 34) timing had higher peak glucose (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.