Evidence map›Paper›PMID 29942867›Full record

ArticleBMJ paediatrics open2018

Drakenstein Child Health Study (DCHS): investigating determinants of early child development and cognition.

Kirsten A Donald, Michelle Hoogenhout, Christopher P du Plooy, Catherine J Wedderburn, Raymond T Nhapi, Whitney Barnett, Nadia Hoffman, Susan Malcolm-Smith, Heather J Zar, Dan J Stein

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ paediatrics open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 53 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Kirsten A DonaldDivision of Developmental Paediatrics, Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-0276-9660
Michelle HoogenhoutDivision of Developmental Paediatrics, Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
Christopher P du PlooyDivision of Developmental Paediatrics, Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
Catherine J WedderburnDivision of Developmental Paediatrics, Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
Raymond T NhapiUnit on Child and Adolescent Health, South African Medical Research Council, Cape Town, South Africa.
Whitney BarnettUnit on Child and Adolescent Health, South African Medical Research Council, Cape Town, South Africa.
Nadia HoffmanDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Susan Malcolm-SmithApplied Cognitive Science and Experimental Neuropsychology Team, Department of Psychology, University of Cape Town, Cape Town, South Africa.
Heather J ZarUnit on Child and Adolescent Health, South African Medical Research Council, Cape Town, South Africa.
Dan J SteinDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.

Funding

Cross-Cultural Assessment of FASDU24AA014811 · NIAAA · SAN DIEGO STATE UNIVERSITY · PI EDWARD P RILEY · 2003 to 2026
$13.1M
A neuroimaging study of 2 year old children with alcohol exposure compared to healthy unexposed controls embedded in a birth cohort studyR21AA023887 · NIAAA · UNIVERSITY OF CAPE TOWN · PI DONALD, KIRSTY · 2016 to 2017
$280k
NIAAA NIH HHS R21 AA023887NIAAA NIH HHS U24 AA014811
6 · The paper itself

Abstract

introductionThere is growing awareness that psychosocial risk and resilience factors in early life play a key role in influencing later health. Most work has been done in high-income settings, rather than low-income and middle-income countries (LMICs), where the majority of the global childhood population resides. The few studies with well-defined cohorts in LMICs have employed various methods and measures, making comparisons across studies challenging. This presentation describes the methodology for infant and child developmental measures used in the Drakenstein Child Health Study (DCHS), a multidisciplinary longitudinal birth cohort study in South Africa. METHODS AND ANALYSIS: We outline a multilevel approach combining a range of measures including parental reports, behaviour observations, clinician-administered scales and brain imaging. Using this approach, we aim at a longitudinal perspective of developmental, cognitive, socioemotional and neurophysiological outcomes in a birth cohort of children in an LMIC. ETHICS AND DISSEMINATION: The study was approved by the faculty of Health Sciences, Human Research Ethics Committee, University of Cape Town (401/2009), Stellenbosch University (N12/02/0002) and the Western Cape Provincial Health Research committee (2011RP45). DISCUSSION: Children in the DCHS develop in a context typical of many communities in South Africa and other LMICs. There is a critical need for research in LMICs to elucidate underlying factors that inform risk for, and resilience to, poor developmental outcomes in infants born into high-risk communities. Such work may inform effective intervention strategies appropriate to this context.

Indexed as

child psychiatryneurodevelopment

Identifiers

PMID29942867
PMCPMC6014194

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.