ArticleScience advances2018
Direct metabolite detection with an n-type accumulation mode organic electrochemical transistor.
Article in Science advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed.
- Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Organic Electrochemical Transistors in Tissue-Interfaced Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Additive Manufacturing of Neuromorphic Systems.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Review
- Balanced Ambipolar OECTs through Tunability of Blend Microstructure.ACS applied materials & interfaces · 2025Article
- In Situ Electropolymerized Ambipolar Copolymers for Vertical OECTs.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Poly(3,4-ethylenedioxythiophene) Nanorod Arrays-Based Organic Electrochemical Transistor for SARS-CoV-2 Spike Protein Detection in Artificial Saliva.ACS sensors · 2025Article
- Wearable Electrochemical Biosensors for Advanced Healthcare Monitoring.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Organic Electrochemical Transistor Aptasensor for Interleukin-6 Detection.ACS applied materials & interfaces · 2024Article
- Reconfiguration of organic electrochemical transistors for high-accuracy potentiometric sensing.Nature communications · 2024Article
- Organic Mixed Ionic-Electronic Conductors for Bioelectronic Sensors: Materials and Operation Mechanisms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Organic Electrochemical Transistors for Biomarker Detections.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Cleanroom-Free Direct Laser Micropatterning of Polymers for Organic Electrochemical Transistors in Logic Circuits and Glucose Biosensors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Coin-sized, fully integrated, and minimally invasive continuous glucose monitoring system based on organic electrochemical transistors.Science advances · 2024Article
- Continuous production of ultratough semiconducting polymer fibers with high electronic performance.Science advances · 2024Article
- Complementary integration of organic electrochemical transistors for front-end amplifier circuits of flexible neural implants.Science advances · 2024Article
- Continuous and Non-Invasive Lactate Monitoring Techniques in Critical Care Patients.Biosensors · 2024Review
- A hybrid transistor with transcriptionally controlled computation and plasticity.Nature communications · 2024Article
- Efficient N-Type Organic Electrochemical Transistors and Field-Effect Transistors Based on PNDI-Copolymers Bearing Fluorinated Selenophene-Vinylene-Selenophenes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Controlling swelling in mixed transport polymers through alkyl side-chain physical cross-linking.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The inherent specificity and electrochemical reversibility of enzymes poise them as the biorecognition element of choice for a wide range of metabolites. To use enzymes efficiently in biosensors, the redox centers of the protein should have good electrical communication with the transducing electrode, which requires either the use of mediators or tedious biofunctionalization approaches. We report an all-polymer micrometer-scale transistor platform for the detection of lactate, a significant metabolite in cellular metabolic pathways associated with critical health care conditions. The device embodies a new concept in metabolite sensing where we take advantage of the ion-to-electron transducing qualities of an electron-transporting (n-type) organic semiconductor and the inherent amplification properties of an ion-to-electron converting device, the organic electrochemical transistor. The n-type polymer incorporates hydrophilic side chains to enhance ion transport/injection, as well as to facilitate enzyme conjugation. The material is capable of accepting electrons of the enzymatic reaction and acts as a series of redox centers capable of switching between the neutral and reduced state. The result is a fast, selective, and sensitive metabolite sensor. The advantage of this device compared to traditional amperometric sensors is the amplification of the input signal endowed by the electrochemical transistor circuit and the design simplicity obviating the need for a reference electrode. The combination of redox enzymes and electron-transporting polymers will open up an avenue not only for the field of biosensors but also for the development of enzyme-based electrocatalytic energy generation/storage devices.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.