Evidence map›Paper›PMID 29942822›Full record

ArticleOpen forum infectious diseases2018

Inflammation Associates With Impaired Small Arterial Elasticity Early in HIV Disease.

Tess E Peterson, Katherine Huppler Hullsiek, Nicole Wyman Engen, Nagalingeswaran Kumarasamy, Anne-Mette Lebech, Angelike Liappis, Antonios Papadopoulos, Mark N Polizzotto, Pamela J Schreiner, Daniel Duprez and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 5 countries.

Tess E PetersonDivision of Epidemiology and Community Health.
Katherine Huppler HullsiekDivision of Biostatistics, University of Minnesota, Minneapolis, Minnesota.
Nicole Wyman EngenDivision of Biostatistics, University of Minnesota, Minneapolis, Minnesota.
Nagalingeswaran KumarasamyYRGCARE Medical Centre, VHS, Chennai, India.
Anne-Mette LebechDepartment of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Angelike LiappisSection of Infectious Diseases, Washington DC Veterans Affairs Medical Center, Washington, DC.
Antonios Papadopoulos4th Department of Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Mark N PolizzottoKirby Institute for Infection and Immunity, University of New South Wales, Sydney, Australia.
Pamela J SchreinerDivision of Epidemiology and Community Health.
Daniel DuprezDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota.
Jason V BakerDepartment of Medicine, University of Minnesota, Minneapolis, Minnesota.
INSIGHT START (Strategic Timing of AntiRetroviral Treatment) Study Group
University of Minnesota · USNational and Kapodistrian University of Athens · GRUniversity of Copenhagen · DKUNSW Sydney · AUYR Gaitonde Centre for AIDS Research and Education · IN

Funding

International Network for Strategic Initiatives in Global HIV Trials (INSIGHT)UM1AI068641 · NIAID · UNIVERSITY OF MINNESOTA · PI NEATON, JAMES DENNIS · 2011 to 2014
$83.5M
International Network for Strategic Initiatives in Global HIV Trials (INSIGHT): STARTUM1AI120197 · NIAID · UNIVERSITY OF MINNESOTA · PI NEATON, JAMES DENNIS · 2015 to 2017
$65.1M
Medical Research Council MC_UU_12023/23NIAID NIH HHS UM1 AI068641NIAID NIH HHS UM1 AI120197
6 · The paper itself

Abstract

We estimated small arterial elasticity and used linear regression to evaluate its association with inflammatory biomarkers among antiretroviral therapy-naïve, HIV-positive patients with high CD4+ counts. After adjustment, high-sensitivity C-reactive protein and interleukin-6 were inversely associated with small arterial elasticity. These data suggest that systemic inflammation may contribute to vascular dysfunction even in very early HIV disease.

Indexed as

arterial elasticitycardiovascular diseaseHIV infectionsystemic inflammationvascular dysfunction

Identifiers

PMID29942822
PMCPMC6007791
OpenAlexW2803830856

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.