Evidence map›Paper›PMID 29942819›Full record

ArticleOpen forum infectious diseases2018

Cerebral Oximetry for Detecting High-mortality Risk Patients with Cryptococcal Meningitis.

John W Diehl, Katherine H Hullsiek, Michael Okirwoth, Nicole Stephens, Mahsa Abassi, Joshua Rhein, David B Meya, David R Boulware, Abdu K Musubire, ASTRO-CM Trial Team

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Cerebrospinal Fluid Lactate as a Prognostic Marker of Disease Severity and Mortality in Cryptococcal Meningitis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  8. Cerebrospinal Fluid Early Fungicidal Activity as a Surrogate Endpoint for Cryptococcal Meningitis Survival in Clinical Trials.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

John W DiehlInfectious Disease Institute, Makerere University, Kampala, Uganda.
Katherine H HullsiekUniversity of Minnesota, Minneapolis, Minnesota.
Michael OkirwothInfectious Disease Institute, Makerere University, Kampala, Uganda.
Nicole StephensUniversity of Minnesota, Minneapolis, Minnesota.
Mahsa AbassiInfectious Disease Institute, Makerere University, Kampala, Uganda.
Joshua RheinInfectious Disease Institute, Makerere University, Kampala, Uganda.
David B MeyaInfectious Disease Institute, Makerere University, Kampala, Uganda.
David R BoulwareUniversity of Minnesota, Minneapolis, Minnesota.
Abdu K MusubireInfectious Disease Institute, Makerere University, Kampala, Uganda.ORCID 0000-0003-2410-5344
ASTRO-CM Trial Team
University of Minnesota System · USEmory University · USMakerere University · UG

Funding

Improving Diagnostics and Neurocognitive Outcomes in HIV/AIDS-related MeningitisR01NS086312 · NINDS · UNIVERSITY OF MINNESOTA · PI David R Boulware, David Bisagaya Meya · 2013 to 2026
$8.3M
Infectious Disease Training in Clinical InvestigationT32AI055433 · NIAID · UNIVERSITY OF MINNESOTA TWIN CITIES · PI David R Boulware · 2003 to 2026
$6.1M
Northern/Pacific Universities Global Health Research Training ConsortiumR25TW009345 · FIC · UNIVERSITY OF WASHINGTON · PI KOLARS, JOSEPH C., NERURKAR, VIVEK RAMCHANDRA · 2012 to 2016
$5.9M
Epidemiology, Immunopathogenesis, and Outcomes of Non-traumatic Spinal Cord Injury in UgandaK43TW010718 · FIC · INFECTIOUS DISEASES INSTITUTE · PI MUSUBIRE, ABDU KISEKKA · 2017 to 2021
$514k
FIC NIH HHS K43 TW010718FIC NIH HHS R25 TW009345Medical Research Council MR/M007413/1NIAID NIH HHS T32 AI055433NINDS NIH HHS R01 NS086312Wellcome Trust
6 · The paper itself

Abstract

background

methodsWe performed cerebral oximetry within 14 days of cryptococcal meningitis diagnosis on 121 Ugandans from April 2016 to September 2017. We evaluated baseline rSO

resultsThe median initial rSO

conclusionsIndividuals with cryptococcal meningitis and low cerebral oximetry (rSO

Indexed as

cerebrovascular circulationcryptococcal meningitishemodynamic monitoringmortalityoximetryphysiologic monitoring

Identifiers

PMID29942819
PMCPMC6007269
OpenAlexW2799283783

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.