ReviewBurns & trauma2018
The venous ulcer continues to be a clinical challenge: an update.
Review in Burns & trauma, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04834232 (Comparative Study Between Iliac Vein Stenting and Compression Therapy in Recurrent Venous Ulceration), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparative Study Between Iliac Vein Stenting and Compression Therapy in Recurrent Venous Ulceration
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Wound cleansing for treating venous leg ulcers.The Cochrane database of systematic reviews · 2021Pooled it
- The Impact of a Multidisciplinary Patient Education Program on Venous Leg Ulcer Healing: A Randomised Controlled Trial.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyTrial
- The Vicious Cycle of Biofilm, Host Inflammation and Microvascular Insufficiency in Venous Leg Ulcers.Medical sciences (Basel, Switzerland) · 2026Review
- Chinese expert consensus on wound repair of venous leg ulcers (2025 edition).Military Medical Research · 2026Article
- Major Common Hallmarks and Potential Epigenetic Drivers of Wound Chronicity and Recurrence: Hypothesis and Reflections.International journal of molecular sciences · 2025Review
- Vascular leakage and angiogenesis in wound healing: a review.Molecular biology reports · 2025Review
- The Journey of Copper-Impregnated Dressings in Wound Healing: From a Medical Hypothesis to Clinical Practice.Biomedicines · 2025Review
- In Vitro and In Vivo Evaluation of Bioactive Compounds from Berries for Wound Healing.Current developments in nutrition · 2024Review
- Designing Composite Stimuli-Responsive Hydrogels for Wound Healing Applications: The State-of-the-Art and Recent Discoveries.Materials (Basel, Switzerland) · 2024Review
- Skin Inflammation with a Focus on Wound Healing.Advances in wound care · 2023Review
- High porosity PEG-based hydrogel foams with self-tuning moisture balance as chronic wound dressings.Journal of biomedical materials research. Part A · 2023Article
- Association between physical activity levels and healing in people with venous leg ulcers: secondary analysis of prospective cohort data.Frontiers in medicine · 2023Article
- Nonhealing venous ulcer in a patient with dystrophic soft tissue calcification.Journal of vascular surgery cases and innovative techniques · 2022Article
- Comparative analysis of endovenous laser ablation versus ultrasound-guided foam sclerotherapy for the treatment of venous leg ulcers.Dermatologic therapy · 2022Article
- Socio-Demographic Characteristics and Associated Factors of Morbidity in Patients with Venous Ulcers Treated in Two Institutions of Contributive and Subsidized Regime in Colombia: Retrospective, Multicenter, Observational Study.Vascular health and risk management · 2022Observational
- Patient and clinician experiences and opinions of the use of a novel home use medical device in the treatment of peripheral vascular disease - a qualitative study.Journal of foot and ankle research · 2021Article
- Article
- Human Wound and Its Burden: Updated 2020 Compendium of Estimates.Advances in wound care · 2021Article
- Virulence and Drug-Resistance ofInternational journal of environmental research and public health · 2021Article
- Topical Sevoflurane: A Novel Treatment for Chronic Pain Caused by Venous Stasis Ulcers.Anesthesiology and pain medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Venous ulcers are a common chronic problem in many countries especially in Northern Europe and USA. The overall prevalence of this condition is 1% rising to 3% in the over 65 years of age. Over the last 25 years, there have been many developments applicable to its diagnosis and treatment. These advances, notwithstanding healing response and recurrence, are variable, and the venous ulcer continues to be a clinical challenge. The pathogenesis of venous ulcers is unrelieved or ambulatory venous hypertension resulting mostly from deep venous thrombosis leading to venous incompetence, lipodermatosclerosis, leucocyte plugging of the capillaries, tissue hypoxia and microvascular dysfunction. It is not known what initiates venous ulcers. Triggers vary from trauma of the lower extremity to scratching to relieve itchy skin over the ankle region. Venous ulcers can be painful, and this condition presents an increasing burden of care. A systematic analysis of the role of technology used for diagnosis and management strongly supports the use of compression as a mainstay of standardised care. It further shows good evidence for the potential of some treatment procedures to accelerate healing. This article reviews the pathogenetic mechanisms, current diagnostic methods and standard care and its limitations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.