Evidence map›Paper›PMID 29942793›Full record

ArticleFrontiers in oncology2018

Blood Serum From Head and Neck Squamous Cell Carcinoma Patients Induces Altered MicroRNA and Target Gene Expression Profile in Treated Cells.

Brittany Allen, Augusto Schneider, Berta Victoria, Yury O Nunez Lopez, Mark Muller, Mateusz Szewczyk, Jakub Pazdrowski, Ewa Majchrzak, Wojciech Barczak, Wojciech Golusinski and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. MicroRNAs targetingMolecular biology research communications · 2024
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. A Review of HPV-Related Head and Neck Cancer.Journal of clinical medicine · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Brittany AllenBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, United States.
Augusto SchneiderFaculdade de Nutrição, Universidade Federal de Pelotas, Pelotas, Brazil.
Berta VictoriaBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, United States.
Yury O Nunez LopezTranslational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, FL, United States.
Mark MullerEpigenetics Division, TopoGEN Inc, Buena Vista, CO, United States.
Mateusz SzewczykDepartment of Head and Neck Surgery, Poznań University of Medical Sciences, The Greater Poland Cancer Centre, Poznan, Poland.
Jakub PazdrowskiDepartment of Head and Neck Surgery, Poznań University of Medical Sciences, The Greater Poland Cancer Centre, Poznan, Poland.
Ewa MajchrzakDepartment of Head and Neck Surgery, Poznań University of Medical Sciences, The Greater Poland Cancer Centre, Poznan, Poland.
Wojciech BarczakDepartment of Head and Neck Surgery, Poznań University of Medical Sciences, The Greater Poland Cancer Centre, Poznan, Poland.
Wojciech GolusinskiDepartment of Head and Neck Surgery, Poznań University of Medical Sciences, The Greater Poland Cancer Centre, Poznan, Poland.
Pawel GolusinskiDepartment of Head and Neck Surgery, Poznań University of Medical Sciences, The Greater Poland Cancer Centre, Poznan, Poland.
Michal M MasternakBurnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL, United States.
Poznan University of Medical Sciences · PLGreater Poland Cancer Center · PLUniversity of Central Florida · USTopoGEN (United States) · USTranslational Research Institute for Metabolism and Diabetes · USUniversidade Federal de Pelotas · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The head and neck squamous cell carcinoma (HNSCC) represents one of the most common cancers in humans. Close to 600,000 new diagnoses are made every year worldwide and over half of diagnosed patients will not survive. In view of this low survival rate, the development of novel cell-based assays for HNSCC will allow more mechanistic approaches for specific diagnostics for each individual patient. The cell-based assays will provide more informative data predicting cellular processes in treated patient, which in effect would improve patient follow up. More importantly, it will increase the specificity and effectiveness of therapeutic approaches. In this study, we investigated the role of serum from HNSCC patients on the regulation of microRNA (miRNA) expression in exposed cells

Indexed as

cancer-associated factorshead and neck squamous cell carcinomasmicroRNAp53 pathwaysequencing data analysis

Identifiers

PMID29942793
PMCPMC6004400
OpenAlexW2806745628

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.