Evidence map›Paper›PMID 29942757›Full record

ArticleIDCases2018

First confirmed case of Powassan neuroinvasive disease in Rhode Island.

Kavin M Patel, Jennie Johnson, Ioannis M Zacharioudakis, Jerrold L Boxerman, Timothy P Flanigan, Rebecca M Reece

Open access · goldAbstract read
In one paragraph

Article in IDCases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. A Fatal Case of Powassan Virus Encephalitis.Journal of Brown hospital medicine · 2024
    Article
  4. Powassan Virus Infections: A Systematic Review of Published Cases.Tropical medicine and infectious disease · 2023
    Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Kavin M PatelDepartment of Medicine, Rhode Island Hospital and Alpert Medical School of Brown University, United States.
Jennie JohnsonDepartment of Infectious Disease, Rhode Island Hospital and Alpert Medical School of Brown University, United States.
Ioannis M ZacharioudakisDepartment of Medicine, Rhode Island Hospital and Alpert Medical School of Brown University, United States.
Jerrold L BoxermanDepartment of Diagnostic Imaging, Rhode Island Hospital and Alpert Medical School of Brown University, United States.
Timothy P FlaniganDepartment of Infectious Disease, Rhode Island Hospital and Alpert Medical School of Brown University, United States.
Rebecca M ReeceDepartment of Infectious Disease, Rhode Island Hospital and Alpert Medical School of Brown University, United States.
Brown University · USRhode Island Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Powassan Virus is the arthropod-borne vector responsible for Powassan neuroinvasive disease. The virus was first isolated in 1958 and has been responsible for approximately 100 cases of neuroinvasive disease. Rates of infection have been on the rise over the past decade with numerous states reporting their first confirmed case; New Jersey, New Hampshire and Connecticut all reported their first case within the last five years. We present here the first confirmed case of Powassan neuroinvasive disease in the nearby state of Rhode Island. A previously healthy 81-year-old female with known tick exposure presented with fever, altered sensorium, seizures and focal neurological deficits. After an extensive work-up that was largely unrevealing Powassan encephalitis was suspected. The diagnosis was confirmed with serological testing consisting of Powassan IgM enzyme-linked immunosorbent assay and Powassan plaque reduction neutralization testing. The case study provides evidence for the increasing spread of Powassan neuroinvasive disease and reinforces the importance of requesting focused testing for Powassan Virus in patients from an endemic area with a clinically compatible syndrome.

Indexed as

CDC, center for disease controlCSF, cerebrospinal fluidCT, computed tomographyELISA, enzyme-linked immunosorbent assayFLAIR, fluid attenuated inversion recoveryMRI, magnetic resonance imagingPowassan encephalitisPOWV, Powassan VirusPRNT, plague reduction neutralization testingTick-borne diseaseViral encephalopathy

Identifiers

PMID29942757
PMCPMC6010959
OpenAlexW2790628831

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.