ArticlePeerJ2018
Patients with chronic periodontitis present increased risk for primary Sjögren syndrome: a nationwide population-based cohort study.
Article in PeerJ, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- The association of periodontal diseases and Sjogren's syndrome: A systematic review and meta-analysis.Frontiers in medicine · 2022Pooled it
- Association between self-reported oral health issues and autoimmune diseases: evidence from UK biobank.BMC oral health · 2026Article
- Increased risk of dry eye disease in Taiwanese patients with chronic periodontitis: A nationwide population-based cohort study.Journal of dental sciences · 2026Article
- Oral Manifestations of Sjögren's Syndrome: Recognition, Management, and Interdisciplinary Care.Medicina (Kaunas, Lithuania) · 2025Review
- Transcriptomic Analysis Reveals C-C Motif Chemokine Receptor 1 as a Critical Pathogenic Hub Linking Sjögren's Syndrome and Periodontitis.Current issues in molecular biology · 2025Article
- Microbial functional pathways based on metatranscriptomic profiling enable effective saliva-based health assessments for precision wellness.Computational and structural biotechnology journal · 2024Article
- Effect of Periodontitis on Dry Eye Disease Signs and Symptoms: A Cross-sectional Study.Oral health & preventive dentistry · 2024Article
- Periodontitis and Sjogren's syndrome: a bidirectional two-sample mendelian randomization study.BMC oral health · 2024Article
- Article
- Identification of venular capillary remodelling: a possible link to the development of periodontitis?Journal of periodontal & implant science · 2022Article
- Burden of chronic diseases associated with periodontal diseases: a retrospective cohort study using UK primary care data.BMJ open · 2021Article
- Characterizing Microbiota from Sjögren's Syndrome Patients.JDR clinical and translational research · 2021Article
- Overlapping Sjogren's syndrome reduces the probability of reaching target in rheumatoid arthritis patients: a propensity score matched real-world cohort from 2009 to 2019.Arthritis research & therapy · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many reports have mentioned the association between chronic periodontitis (CP) and primary Sjögren syndrome (pSS). However, no cohort study has been performed for the risk of pSS in patients with CP. In this study, we evaluated the risk of pSS from CP exposure in a nationwide population-based cohort study in Taiwan. We studied the claims data of Taiwanese population from 2001 to 2012. We identified 76,765 patients with CP from the National Health Insurance Database in Taiwan. We also selected 76,765 controls that were randomly frequency matched by age, sex, and index year from the general population. We analyzed the risk of pSS by using Cox proportional hazards regression models including sex, age, and comorbidities. In this study, 76,765 patients with CP (mean age: 40.8 years) and 76,765 controls (mean age: 41.0 years) were followed-up for 8.54 and 8.49 years, respectively. A total of 869 cases of pSS were identified in CP cohort and 483 cases in non-CP cohort. Multivariate Cox regression analysis indicated that the incidence rate of pSS was significantly higher in CP cohort than those who in non-CP cohort (adjusted HR: 1.79, 95% CI [1.60-2.00]). Taken together, this nationwide retrospective cohort study demonstrated that the risk of pSS was significantly higher in patients with CP than in the general population. The association between CP and pSS was significant in the female group.
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