Evidence map›Paper›PMID 29942654›Full record

ArticleVirus evolution2018

Selective constraint and adaptive potential of West Nile virus within and among naturally infected avian hosts and mosquito vectors.

Chase W Nelson, Samuel D Sibley, Sergios-Orestis Kolokotronis, Gabriel L Hamer, Christina M Newman, Tavis K Anderson, Edward D Walker, Uriel D Kitron, Jeffrey D Brawn, Marilyn O Ruiz and 1 more

Open access · goldAbstract read
In one paragraph

Article in Virus evolution, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  7. Article
  8. Review
  9. Many human RNA viruses show extraordinarily stringent selective constraints on protein evolution.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  10. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Chase W NelsonSackler Institute for Comparative Genomics, American Museum of Natural History, New York, NY 10024, USA.
Samuel D SibleyDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
Sergios-Orestis KolokotronisSackler Institute for Comparative Genomics, American Museum of Natural History, New York, NY 10024, USA.ORCID 0000-0003-3309-8465
Gabriel L HamerDepartment of Entomology, Texas A&M University, College Station, TX 77843-2475, USA.
Christina M NewmanDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.
Tavis K AndersonDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0002-3138-5535
Edward D WalkerDepartment of Microbiology and Molecular Genetics, Michigan State University, Lansing, MI 48824-4320, USA.
Uriel D KitronDepartment of Environmental Studies, Emory University, Atlanta, GA 30322, USA.
Jeffrey D BrawnDepartment of Natural Resources and Environmental Sciences, University of Illinois, Urbana, IL 61801, USA.
Marilyn O RuizDepartment of Pathobiology, University of Illinois, Urbana, IL 61802, USA.
Tony L GoldbergDepartment of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI 53706, USA.ORCID 0000-0003-3962-4913
University of Wisconsin–Madison · USAmerican Museum of Natural History · USEmory University · USIllinois Department of Natural Resources · USMichigan State University · USTexas A&M University · USUniversity of Illinois Urbana-Champaign · US

Funding

Parasitology and Vector Biology Training ProgramT32AI007414 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI Lyric Colleen Bartholomay · 1992 to 2026
$4.5M
NIAID NIH HHS T32 AI007414
6 · The paper itself

Abstract

Arthropod-borne viruses are among the most genetically constrained RNA viruses, yet they have a remarkable propensity to adapt and emerge. We studied wild birds and mosquitoes naturally infected with West Nile virus (WNV) in a 'hot spot' of virus transmission in Chicago, IL, USA. We generated full coding WNV genome sequences from spatiotemporally matched bird and mosquito samples using high-throughput sequencing, allowing a molecular evolutionary assessment with deep coverage. Mean

Indexed as

adaptationarbovirusdeep sequencingflavivirushosthost/pathogeninterhostintrahostmolecular evolutionnatural infectionnatural selectionnonsynonymousnucleotide diversitypopulation geneticssynonymousvectorWest Nile virus

Identifiers

PMID29942654
PMCPMC6007309
OpenAlexW2807890555

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.