Evidence map›Paper›PMID 29942453›Full record

ArticleIranian journal of basic medical sciences2018

Radiosensitizing effects of Sestrin2 in PC3 prostate cancer cells.

Hao Fu, Wenke Song, Yufei Wang, Wenyi Deng, Tingting Tang, Wenjing Fan, Shunlin Qu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Iranian journal of basic medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Sestrin2 in cancer: a foe or a friend?Biomarker research · 2022
    Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hao FuDepartment of Urology, Affiliated Nanhua Hospital of University of South China, 336 South Dongfeng Road, Hengyang, 421002, Hunan Province, China.
Wenke SongDepartment of Obstetrics and Gynaecology, Affiliated Nanhua Hospital of University of South China, 336 South Dongfeng Road, Hengyang, 421002, Hunan Province, China.
Yufei WangPathophysiology Department, University of South China, Hengyang City, Hunan Province, PRC, 421001.
Wenyi DengPathophysiology Department, University of South China, Hengyang City, Hunan Province, PRC, 421001.
Tingting TangPathophysiology Department, University of South China, Hengyang City, Hunan Province, PRC, 421001.
Wenjing FanPathophysiology Department, University of South China, Hengyang City, Hunan Province, PRC, 421001.
Shunlin QuPathophysiology Department, University of South China, Hengyang City, Hunan Province, PRC, 421001.
University of South China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe stress-responsive genes of Sestrin family are recognized as new tumor suppressor genes in breast carcinoma, however, the function of Sestrin family in human prostate cancer is not clear. Ionizing radiation (IR) is known to induce Sestrin gene expression in breast cancer cells. However, the response of Sestrin to IR has not been reported in PC3 prostate cancer cells. MATERIALS AND

methodsSestrin2 expression in prostate cancer cell lines (PC3, LNCaP clone FGC, and DU145) was detected by Western blot and real-time PCR. Cell counting kit (CCK-8) was used to detect cellular proliferation. The radiosensitivity of PC3 cells was detected by clonogenic assay.

resultsSestrin2 expression in prostate cancer cell lines (PC3, LNCaP clone FGC, and DU145) is low. In vitro assays indicated that over-expressing Sestrin2 in human prostate cancer PC3 inhibited tumor proliferation. In addition, elevated Sestrin2 expression sensitized PC3 cells to IR.

conclusionWe determined Sestrin2 may function as a tumor suppressor through repressing proliferation, mediating sensitization to IR in PC3 cells.

Indexed as

CancerProstateRadiationSensitizationSestrin2

Identifiers

PMID29942453
PMCPMC6015252
OpenAlexW2800197015

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.