Evidence map›Paper›PMID 29942445›Full record

ArticleIranian journal of basic medical sciences2018

Protective role of HLA-DRB1*11 against juvenile idiopathic arthritis living in North Eastern Iran.

Zahra Rezaieyazdi, Morteza Kochakzadeh, Mohammad Reza Hatef, Habibollah Esmaily, Abdolreza Malek, Narges Valizadeh, Samira Tabaei, Houshang Rafatpanah

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PubMed Full text at PMC Publisher
In one paragraph

Article in Iranian journal of basic medical sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Zahra RezaieyazdiRheumatic Disease Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Morteza KochakzadehRheumatic Disease Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Mohammad Reza HatefRheumatic Disease Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Habibollah EsmailySocial Determination of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Abdolreza MalekDepartment of Pediatrics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Narges ValizadehImmunology Research Center, Inflammation and Inflammatory Diseases Division, Mashhad University of Medical Sciences, Mashhad, Iran.
Samira TabaeiRheumatic Disease Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Houshang RafatpanahImmunology Research Center, Inflammation and Inflammatory Diseases Division, Mashhad University of Medical Sciences, Mashhad, Iran.
Mashhad University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesJuvenile idiopathic arthritis (JIA) is one of the most common chronic rheumatic diseases in children. The complex nature of this immune-mediated disease owes itself to several predisposing genes and environmental factors affecting its pathogenesis. Conducted in Iran, this study was originally intended to investigate every possible association between HLA DRB1 alleles and a susceptibility to JIA. MATERIALS AND

methodsIn this case-control study, 45 patients with a definite diagnosis of JIA based on International League against Rheumatism (ILAR) criteria were compared against 46 healthy controls. DNA samples taken from both groups were analyzed using PCR-sequence specific primers (PCR-SSP) method. Data analysis including parametric and nonparametric test and multivariate analysis was undertaken using the SPSS 11.5 software. A

resultsMean ages in case group and healthy controls were 14.64±6.21 and 13.73±6.39, respectively with no significant difference between the two groups (

conclusionHLA-DRB1*11 was shown to raise protection to JIA in northeastern Iran. The disparity of findings in other ethnicities prompts further investigations with larger sample sizes.

Indexed as

Allele frequencyHLA-DRB1HLA typingJuvenile idiopathic arthritisPCR-SSP

Identifiers

PMID29942445
PMCPMC6015248
OpenAlexW2808881885

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.