Evidence map›Paper›PMID 29942347›Full record

ArticleInfectious agents and cancer2018

Clinico-pathological features of oropharyngeal squamous cell carcinomas in Malaysia with reference to HPV infection.

Lee Fah Yap, Sook Ling Lai, Anthony Rhodes, Hans Prakash Sathasivam, Maizaton Atmadini Abdullah, Kin-Choo Pua, Pathmanathan Rajadurai, Phaik-Leng Cheah, Selvam Thavaraj, Max Robinson and 1 more

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Article in Infectious agents and cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Article
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lee Fah Yap1Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.
Sook Ling Lai1Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.
Anthony Rhodes3School of Medicine, Taylor's University, Subang Jaya, Selangor Malaysia.
Hans Prakash Sathasivam4Centre for Oral Health Research, Newcastle University, Newcastle-upon-Tyne, UK.
Maizaton Atmadini Abdullah6Faculty of Medicine and Health Sciences, University Putra Malaysia, Serdang, Malaysia.
Kin-Choo PuaPenang General Hospital, Penang, Malaysia.
Pathmanathan Rajadurai8Subang Jaya Medical Centre, Subang Jaya, Selangor Malaysia.
Phaik-Leng Cheah9Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Selvam Thavaraj10Head and Neck Pathology, Dental Institute, King's College London, London, UK.
Max Robinson4Centre for Oral Health Research, Newcastle University, Newcastle-upon-Tyne, UK.
Ian C Paterson1Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia.ORCID 0000-0001-9156-401X

Funding

Medical Research Council MR/N005872/1
6 · The paper itself

Abstract

backgroundThe incidence of oropharyngeal squamous cell carcinoma (OPSCC) has been rising in Western countries and this has been attributed to human papillomavirus (HPV) infection. p16 expression is a marker for HPV infection and p16 positive OPSCC is now recognized as a separate disease entity. There are only limited data available regarding HPV-related OPSCC in Asian countries and no data from Malaysia.

methodsWe identified 60 Malaysian patients with OPSCC over a 12-year period (2004-2015) from four different hospitals in two major cities, Kuala Lumpur and Penang. The detection of HPV was carried out using p16 immunohistochemistry and high risk HPV DNA in situ hybridisation.

resultsOverall, 15 (25%) tumours were p16 positive by immunohistochemistry, 10 of which were also positive for high risk HPV DNA by in situ hybridisation. By comparison, a matched cohort of UK patients had a p16 positive rate of 49%. However, between 2009 and 2015, where cases were available from all four hospitals, 13 of 37 (35%) cases were p16 positive. In our Malaysian cohort, 53% of patients were of Chinese ethnicity and 80% of the p16 positive cases were found in these patients; no Indian patients had p16 positive disease, despite representing 35% of the total cohort.

conclusionThe proportion of OPSCCs associated with HPV in Malaysia appears to be lower than in European and American cohorts and could possibly be more prevalent amongst Malaysians of Chinese ethnicity. Further, our data suggests that the burden of HPV-related OPSCC could be increasing in Malaysia. Larger cross-sectional studies of Malaysian patients are required to determine the public health implications of these preliminary findings.

Indexed as

Human papillomavirusMalaysiaOropharyngealp16Squamous cell carcinoma

Identifiers

PMID29942347
PMCPMC5996537

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