Evidence map›Paper›PMID 29942303›Full record

ArticleFrontiers in immunology2018

The Prognostic Value of Immune Factors in the Tumor Microenvironment of Penile Squamous Cell Carcinoma.

Sarah Rosanne Ottenhof, Rosa Sanne Djajadiningrat, Helene Hoegsbro Thygesen, Pamela Josephine Jakobs, Katarzyna Jóźwiak, Anne Marijne Heeren, Jeroen de Jong, Joyce Sanders, Simon Horenblas, Ekaterina Straschimirova Jordanova

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 2 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 2 syntheses or guidelines pooled it, 104 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Prognostic value of the tumor immune microenvironment, PD-L1 and p16Virchows Archiv : an international journal of pathology · 2026
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  18. Tumor-infiltrating plasma cells are a prognostic factor in penile squamous cell carcinoma.Virchows Archiv : an international journal of pathology · 2025
    Article
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Sarah Rosanne OttenhofDepartment of Urology, Netherlands Cancer Institute, Amsterdam, Netherlands.
Rosa Sanne DjajadiningratDepartment of Urology, Netherlands Cancer Institute, Amsterdam, Netherlands.
Helene Hoegsbro ThygesenDepartment of Biometrics, Netherlands Cancer Institute, Amsterdam, Netherlands.
Pamela Josephine JakobsDepartment of Urology, Netherlands Cancer Institute, Amsterdam, Netherlands.
Katarzyna JóźwiakDepartment of Epidemiology and Biostatistics, Netherlands Cancer Institute, Amsterdam, Netherlands.
Anne Marijne HeerenCenter for Gynecologic Oncology Amsterdam (CGOA), VU University Medical Center, Amsterdam, Netherlands.
Jeroen de JongDepartment of Pathology, Netherlands Cancer Institute, Amsterdam, Netherlands.
Joyce SandersDepartment of Pathology, Netherlands Cancer Institute, Amsterdam, Netherlands.
Simon HorenblasDepartment of Urology, Netherlands Cancer Institute, Amsterdam, Netherlands.
Ekaterina Straschimirova JordanovaCenter for Gynecologic Oncology Amsterdam (CGOA), VU University Medical Center, Amsterdam, Netherlands.
The Netherlands Cancer Institute · NLAmsterdam UMC Location VUmc · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The host's immune system plays a pivotal role in many tumor types, including squamous cell carcinomas (SCCs). We aim to identify immunological prognosticators for lymph node metastases (LNM) and disease-specific survival (DSS) in penile SCC. For this retrospective observational cohort study, penile SCC patients (

Indexed as

AgedB7-H1 AntigenBiomarkersCarcinoma, Squamous CellFollow-Up StudiesHumansImmunologic FactorsLymphocytes, Tumor-InfiltratingMacrophagesMaleMiddle AgedNeoplasm StagingNetherlandsOdds RatioPapillomavirus InfectionsPenile NeoplasmsB7-H1 AntigenBiomarkersCD274 protein, humanImmunologic FactorsB7-H1HPVimmune escapemicroenvironmentpenile cancerprogrammed death ligand-1squamous cell carcinomaT-cells

Identifiers

PMID29942303
PMCPMC6004546
OpenAlexW2803451300

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.