Evidence map›Paper›PMID 29942123›Full record

ArticleInternational journal of chronic obstructive pulmonary disease2018

Can CAPTURE be used to identify undiagnosed patients with mild-to-moderate COPD likely to benefit from treatment?

Nancy K Leidy, Fernando J Martinez, Karen G Malley, David M Mannino, MeiLan K Han, Elizabeth D Bacci, Randall W Brown, Julia F Houfek, Wassim W Labaki, Barry J Make and 5 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of chronic obstructive pulmonary disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01880177 (A Study Designed to Develop and Validate a New Screening Measure for Identifying Undiagnosed At-Risk COPD Cases), which is not on this map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01880177 completednot on this map

A Study Designed to Develop and Validate a New Screening Measure for Identifying Undiagnosed At-Risk COPD Cases

TypeobservationalSponsorUniversity of MichiganRan2013 to 2015Enrolled346ConditionsChronic Obstructive Pulmonary Disease (COPD)
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. The Use of Lung Cancer Screening to Increase Chronic Obstructive Pulmonary Disease Diagnosis in Veterans Affairs Primary Care.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Early diagnosis of COPD: myth or a true perspective.European respiratory review : an official journal of the European Respiratory Society · 2020
    Review
  13. Article
  14. COPD and Rural Health: A Dialogue on the National Action Plan.The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 11 institutions in 2 countries.

Nancy K LeidyEvidera, Patient-Centered Research, Bethesda, MD, USA.
Fernando J MartinezWeill Cornell Medicine, Joan & Sanford Weill Department of Medicine, New York, NY, USA.
Karen G MalleyEvidera, Patient-Centered Research, Bethesda, MD, USA.
David M ManninoUniversity of Kentucky, Preventive Medicine & Environmental Health, Lexington, KY, USA.
MeiLan K HanUniversity of Michigan, Division of Pulmonary & Critical Care Medicine, Ann Arbor, MI, USA.
Elizabeth D BacciEvidera, Patient-Centered Research, Seattle, WA, USA.
Randall W BrownUniversity of Michigan, Department of Health Behavior & Health Education, School of Public Health, Ann Arbor, MI, USA.
Julia F HoufekUniversity of Nebraska Medical Center College of Nursing, Omaha, NE, USA.
Wassim W LabakiUniversity of Michigan, Division of Pulmonary & Critical Care Medicine, Ann Arbor, MI, USA.
Barry J MakeNational Jewish Health, Department of Medicine, Division of Pulmonary, Critical Care & Sleep Medicine, Denver, CO, USA.
Catherine A MeldrumUniversity of Michigan, Division of Pulmonary & Critical Care Medicine, Ann Arbor, MI, USA.
Wilson QuezadaColumbia University Medical Center, Division of Pulmonary, Allergy, & Critical Care, New York, NY, USA.
Stephen RennardAstraZeneca, IMED Biotech Unit, Cambridge, UK & University of Nebraska Medical Center, Department of Medicine, Omaha, NE, USA.
Byron ThomashowColumbia University Medical Center, Division of Pulmonary, Allergy, & Critical Care, New York, NY, USA.
Barbara P YawnUniversity of Minnesota, Department of Family & Community Health, Minneapolis, MN & COPD Foundation, Miami, FL, USA.
Michigan Medicine · USColumbia University Irving Medical Center · USGramercy Research Group (United States) · USCornell University · USMichigan Department of Health and Human Services · USNational Jewish Health · USPatient-Centered Outcomes Research Institute · USUniversity of Kentucky · USUniversity of Minnesota · USUniversity of Nebraska at Omaha · USUniversity of Nebraska Medical Center · US

Funding

Metabolomic signatures of empysema and COPD progression in the COPDGene cohortR01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2012 to 2016
$31.1M
(2 of 2) Genetic Epidemiology of COPDR01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2012 to 2016
$18.9M
Design and Testing of tools to Identify individuals at high risk for COPD^ 73R01HL114055 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI LEIDY, NANCY KLINE, MANNINO, DAVID · 2012 to 2014
$2.4M
NHLBI NIH HHS R01 HL089856NHLBI NIH HHS R01 HL089897NHLBI NIH HHS R01 HL114055
6 · The paper itself

Abstract

Background: COPD Assessment in Primary Care To Identify Undiagnosed Respiratory Disease and Exacerbation Risk (CAPTURE™) uses five questions and peak expiratory flow (PEF) thresholds (males ≤350 L/min; females ≤250 L/min) to identify patients with a forced expiratory volume in 1 second (FEV Methods: Data from the CAPTURE development study were used to test its sensitivity (SN) and specificity (SP) differentiating mild-to-moderate COPD (n=73) from no COPD (n=87). SN and SP for differentiating all COPD cases (mild to severe; n=259) from those without COPD (n=87) were also estimated. The modified Medical Research Council (mMRC) dyspnea scale and COPD Assessment Test (CAT™) were used to evaluate symptoms and health status. Clinical Trial Registration: NCT01880177, https://ClinicalTrials.gov/ct2/show/NCT01880177?term=NCT01880177&rank=1. Results: Mean age (+SD): 61 (+10.5) years; 41% male. COPD: FEV Conclusion: CAPTURE (450/350) may be useful for identifying symptomatic patients with mild-to-moderate airflow obstruction in need of diagnostic evaluation for COPD.

Indexed as

Surveys and QuestionnairesAgedAged, 80 and overCase-Control StudiesCross-Sectional StudiesDisease ProgressionFemaleForced Expiratory VolumeHumansMaleMiddle AgedProspective StudiesPulmonary Disease, Chronic ObstructiveSensitivity and SpecificitySymptom AssessmentVital Capacitycase-findingCOPDpeak expiratory flowscreening toolundiagnosed COPD

Identifiers

PMID29942123
PMCPMC6005334
OpenAlexW2807876369

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.