Evidence map›Paper›PMID 29941957›Full record

ArticleNature communications2018

Arousal dependent modulation of thalamo-cortical functional interaction.

Iain Stitt, Zhe Charles Zhou, Susanne Radtke-Schuller, Flavio Fröhlich

Registry-linked trialAbstract read
In one paragraph

Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04031404 (Modulation of Motor Cortex Excitability by Glucose Administration), which is not on this map. Cited by 47 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04031404 naterminatednot on this mapstarted 2019, after this paper: background citation

Modulation of Motor Cortex Excitability by Glucose Administration

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2019 to 2020Enrolled23ConditionsGlucose Metabolism DisordersArmsSingle-pulse TMS
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Visualization of functional and effective connectivity underlying auditory descriptive naming.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025
    Article
  9. Article
  10. Role of the Medial Posterior Parietal Cortex in Orchestrating Attention and Reaching.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Iain StittDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Zhe Charles ZhouDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Susanne Radtke-SchullerDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Flavio FröhlichDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. flavio_frohlich@med.unc.edu.ORCID http://orcid.org/0000-0002-3724-5621

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ongoing changes in arousal influence sensory processing and behavioral performance. Yet the circuit-level correlates for this influence remain poorly understood. Here, we investigate how functional interaction between posterior parietal cortex (PPC) and lateral posterior (LP)/Pulvinar is influenced by ongoing fluctuations in pupil-linked arousal, which is a non-invasive measure of neuromodulatory tone in the brain. We find that fluctuations in pupil-linked arousal correlate with changes to PPC to LP/Pulvinar oscillatory interaction, with cortical alpha oscillations driving activity during low arousal states, and LP/Pulvinar driving PPC in the theta frequency band during higher arousal states. Active visual exploration by saccadic eye movements elicits similar transitions in thalamo-cortical interaction. Furthermore, the presentation of naturalistic video stimuli induces thalamo-cortical network states closely resembling epochs of high arousal in the absence of visual input. Thus, neuromodulators may play a role in dynamically sculpting the patterns of thalamo-cortical functional interaction that underlie visual processing.

Indexed as

Photic StimulationAnimalsArousalFemaleFerretsNeural PathwaysParietal LobePulvinarSaccadesThalamusTheta RhythmVisual Cortex

Identifiers

PMID29941957
PMCPMC6018110

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.