ArticleNature cell biology2018
Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours.
Erratum issuedAbstract read
In one paragraph
Article in Nature cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 293 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
293citing papers in PubMed, 2 pooled it
14.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
293 citing papers in PubMed, 2 syntheses or guidelines pooled it, 447 citations in OpenAlex.
- A multimodal atlas of tumour metabolism reveals the architecture of gene-metabolite covariation.Nature metabolism · 2023Pooled it
- The role of glutamate receptors in the regulation of the tumor microenvironment.Frontiers in immunology · 2023Pooled it
- A nomogram based on metabolic profiling to discriminate lung cancer among patients with lung nodules.The Journal of international medical research · 2023Trial
- Saccharopine and α-Aminoadipic Acid as Potential Biomarkers for Mitochondrial Stress in Neurons.Cells · 2026Article
- Remodeling of mitochondrial dynamics by metabolic pathways couples to oncogenic growth inScience advances · 2026Article
- Nicotinamide nucleotide transhydrogenase directly couples redox homeostasis to proline biosynthesis in human glioma.Molecular cell · 2026Article
- Loss of TCA cycle turning promotes stem cell function.bioRxiv : the preprint server for biology · 2026Article
- Review
- Article
- Mixed-Ligand Complex Formation in the Systems Containing the Potential Drug [VIVO(acac)2] with Blood and Cellular Bioligands. Implications on the Active Species Formed in the Organism.Inorganic chemistry · 2026Article
- Transsulfuration links aspartate-asparagine metabolism and redox homeostasis to drive tumor growth: Asparagine-driven transsulfuration bypasses the malate-aspartate shuttle to restore redox balance, revealing a metabolic vulnerability in tumor redox maintenance.bioRxiv : the preprint server for biology · 2026Article
- Aspartate Transporter SLC1A3 Promotes Colorectal Cancer via MDM2-p53 Pathway and M2 Macrophage Polarization.Cancer science · 2026Article
- Dysregulation of the urea cycle - potential targets for treatment and diagnosis in prostate cancer.Expert reviews in molecular medicine · 2026Review
- Structure-guided optimization of SLC1A1/EAAT3-selective inhibitors targeting renal cancer metabolism.The EMBO journal · 2026Article
- Amino Acids as Targets for Immunotherapy against Solid Tumors.Cell biochemistry and biophysics · 2026Review
- Succinate dehydrogenase loss suppresses pyrimidine biosynthesis via succinate-mediated inhibition of aspartate transcarbamylase.Nature metabolism · 2026Article
- Aspartate deficiency amplifies cGAS-STING signaling in antitumor immunity.The Journal of clinical investigation · 2026Article
- Mitochondrial copper stabilizes lipoylated TCA cycle proteins to sustain metabolism and proliferation.bioRxiv : the preprint server for biology · 2026Article
- Targeting SCAMP2 by a natural product auxarconjugatin B for glioblastoma therapyActa pharmaceutica Sinica. B · 2026Article
- Nitrogen Isotope Effects in Urea Metabolism: From Biochemistry toInternational journal of molecular sciences · 2026Review
233 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
12 authors at 3 institutions in 1 country.
Javier Garcia-BermudezLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.
Lou BaudrierLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.
Konnor LaLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.
Xiphias Ge ZhuLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA.
Justine FidelinProteomics Resource Center, The Rockefeller University, New York, NY, USA.
Vladislav O SviderskiyDepartment of Pathology, New York University School of Medicine, New York, NY, USA.
Thales PapagiannakopoulosDepartment of Pathology, New York University School of Medicine, New York, NY, USA.
Henrik MolinaProteomics Resource Center, The Rockefeller University, New York, NY, USA.
Matija SnuderlDepartment of Pathology, New York University School of Medicine, New York, NY, USA.
Caroline A LewisWhitehead Institute for Biomedical Research, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-1787-5084
Richard L PossematoDepartment of Pathology, New York University School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-2401-0030
Kıvanç BirsoyLaboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY, USA. kbirsoy@rockefeller.edu.ORCID http://orcid.org/0000-0002-7579-9895
Rockefeller University · USNew York University · USWhitehead Institute for Biomedical Research · US
Funding
MEDICAL SCIENTIST TRAININGT32GM007308 · NIGMS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PHILIPS, MARK REID · 1985 to 2019
$23.2MIdentifying metabolic dependencies in genetic subtypes of KRAS-driven lung cancerR37CA222504 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PAPAGIANNAKOPOULOS, THALES · 2018 to 2024
$3.3MDissecting tumor metabolic heterogeneity in vivoDP2CA228042 · NCI · ROCKEFELLER UNIVERSITY · PI BIRSOY, KIVANC · 2017 to 2017
$2.5MTargeting Metabolic Liabilities in CancerR01CA214948 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI POSSEMATO, RICHARD LEWIS · 2018 to 2022
$1.9MUncovering Genotype Specific Vulnerabilities in KRAS Mutant Lung Cancer?R01CA227649 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PAPAGIANNAKOPOULOS, THALES · 2018 to 2022
$1.9MElucidating the role of the Nrf2 anti-oxidant pathway in lung adenocarcinomaK22CA201088 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PAPAGIANNAKOPOULOS, THALES · 2016 to 2018
$570kMetabolic liabilities of cancer cells to the tumor nutrient environmentK22CA193660 · NCI · ROCKEFELLER UNIVERSITY · PI BIRSOY, KIVANC · 2016 to 2018
$542kRapid Determination of Phenotypic Responses Across Cancer Cell LinesR21CA198543 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI POSSEMATO, RICHARD LEWIS · 2015 to 2016
$406kNCI NIH HHS DP2 CA228042NCI NIH HHS K22 CA193660NCI NIH HHS K22 CA201088NCI NIH HHS R01 CA214948NCI NIH HHS R01 CA227649NCI NIH HHS R21 CA198543NCI NIH HHS R37 CA222504NIGMS NIH HHS T32 GM007308
Abstract
As oxygen is essential for many metabolic pathways, tumour hypoxia may impair cancer cell proliferation
Indexed as
Cell ProliferationEnergy MetabolismTumor HypoxiaTumor MicroenvironmentAdultAgedAged, 80 and overAnimalsAntineoplastic AgentsAspartic AcidBiological TransportCell Line, TumorElectron Transport Chain Complex ProteinsExcitatory Amino Acid Transporter 1HumansMetabolomicsAntineoplastic AgentsAspartic AcidElectron Transport Chain Complex ProteinsExcitatory Amino Acid Transporter 1SLC1A3 protein, human
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.