ArticleNature cell biology2018
Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism.
Abstract readComparative Study
In one paragraph
Article in Nature cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
140 citing papers in PubMed, 1 synthesis or guideline pooled it, 197 citations in OpenAlex.
- Mechanisms of obesity- and diabetes mellitus-related pancreatic carcinogenesis: a comprehensive and systematic review.Signal transduction and targeted therapy · 2023Pooled it
- Remodeling of mitochondrial dynamics by metabolic pathways couples to oncogenic growth inScience advances · 2026Article
- Conserved Metastatic Cell States and Spatial Immune Microenvironment Remodeling Define Pancreatic Cancer Liver Metastases.bioRxiv : the preprint server for biology · 2026Article
- Propionyl-CoA catabolism is a metabolic gatekeeper for fatty acid oxidation in pancreatic cancer.Oncogene · 2026Article
- Inhibitory probes for spatiotemporal analysis of GαNature chemical biology · 2026Article
- Pancreatic Cancer-Advances in the Last 50 Years.World journal of surgery · 2026Review
- Molecular pathology of intraductal papillary mucinous neoplasms of the pancreas: current understanding and perspectives on malignant progression.Journal of gastroenterology · 2026Review
- Metabolic plasticity in pancreatic ductal adenocarcinoma progression and response to treatment.Molecular cancer · 2026Review
- Protein kinase a regulates cyclooxygenase-2 expression through the RNA-binding proteins HuR and TTP.The Journal of biological chemistry · 2026Article
- Pancreatic cancer: molecular pathogenesis and emerging therapeutic strategies.Signal transduction and targeted therapy · 2026Review
- Prognostic value of salt-inducible kinase 2 expression in advanced hepatocellular carcinoma treated with sorafenib or lenvatinib: a propensity score-matched cohort study.American journal of cancer research · 2026Article
- The tumour microenvironment in pancreatic cancer - new clinical challenges, but more opportunities.Nature reviews. Clinical oncology · 2025Review
- Enhanced Selenium Supplement Extends Lifespan and Delays Multi-Organs Aging by Regulating the Sik1 Pathway Through Maintaining Calcium Homeostasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Serum gamma-glutamyl transferase level is associated with the risk of pancreatic cystic neoplasms: A nationwide retrospective cohort study.World journal of gastroenterology · 2025Article
- GNAS/PKA signaling promotes aberrant osteochondral differentiation of Gli1The EMBO journal · 2025Article
- Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors.Molecular oncology · 2025Article
- A Case of Adipophilin-Positive Pancreatic Intraductal Papillary Mucinous Neoplasm (IPMN) With Eosinophilia.Cureus · 2025Article
- Article
- Unraveling the link between GNAS R201 mutation and colorectal cancer.Scientific reports · 2025Article
- The Hippo signaling pathway modulates pancreatic tissue homeostasis.Cell death discovery · 2025Review
80 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 6 institutions in 5 countries.
Krushna C PatraCenter for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
Yasutaka KatoCenter for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
Yusuke MizukamiCenter for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
Sebastian WidholzCenter for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
Myriam BoukhaliCenter for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
Iulia RevencoCenter for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
Elizabeth A GrossmanDepartments of Nutritional Sciences and Toxicology, Chemistry, and Molecular and Cell Biology, University of California, Berkeley, CA, USA.
Fei JiDepartments of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
Ruslan I SadreyevCenter for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
Andrew S LissCenter for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
Robert A ScreatonSunnybrook Research Institute, Toronto, Ontario, Canada.
Kei SakamotoMRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Scotland, UK.
David P RyanCenter for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
Mari Mino-KenudsonCenter for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
Carlos Fernandez-Del CastilloCenter for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
Daniel K NomuraDepartments of Nutritional Sciences and Toxicology, Chemistry, and Molecular and Cell Biology, University of California, Berkeley, CA, USA.
Wilhelm HaasCenter for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
Nabeel BardeesyCenter for Cancer Research, Massachusetts General Hospital, Boston, MA, USA. Bardeesy.Nabeel@mgh.harvard.edu.ORCID http://orcid.org/0000-0003-3867-0416
Harvard University · USMassachusetts General Hospital · USUniversity of California, Berkeley · USAsahikawa Medical University · JPUniversity of Dundee · GBUniversity of Toronto · CA
Funding
The RAS and P13K Pathways in Pancreatic AdenocarcinomaP01CA117969 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DEPINHO, RONALD ANTHONY · 2006 to 2025
$41.7MTissue and Pathology ResourcesP50CA127003 · NCI · DANA-FARBER CANCER INST · PI EL-BARDEESY, NABEEL, SELLERS, WILLIAM R · 2007 to 2023
$33.2MROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER P DUGGAN · 1994 to 2026
$31.6MTGF-beta Signaling in Pancreatic CancerR01CA133557 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI EL-BARDEESY, NABEEL · 2008 to 2013
$1.7MNCI NIH HHS P01 CA117969NCI NIH HHS P50 CA127003NCI NIH HHS R01 CA133557NIDDK NIH HHS P30 DK040561
Abstract
G protein α
Indexed as
MutationAnimalsCarcinoma, Pancreatic DuctalCell Line, TumorCell Transformation, NeoplasticCellular ReprogrammingChromograninsCyclic AMP-Dependent Protein KinasesEnzyme RepressionFatty AcidsFemaleGene Expression Regulation, NeoplasticGenes, rasGenetic Predisposition to DiseaseGTP-Binding Protein alpha Subunits, GsHumansChromograninsCyclic AMP-Dependent Protein KinasesFatty AcidsGNAS protein, humanGnas protein, mouseGTP-Binding Protein alpha Subunits, GsProtein Serine-Threonine Kinasessalt-inducible kinase-2, mouseSIK1 protein, humanSIK3 protein, mouseTrp53 protein, mouseTumor Suppressor Protein p53
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.