ArticleNature chemistry2018
Non-aqueous homogenous biocatalytic conversion of polysaccharides in ionic liquids using chemically modified glucosidase.
Article in Nature chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 102 citations in OpenAlex.
- Stoichiometrically Engineered Hydrated Ionic Liquids Enabling Reinforcement of Enzyme Cascade with Improved Thermodynamic Stability.ACS sustainable chemistry & engineering · 2026Article
- Engineering LmrR protein for L-proline-based asymmetric aldol biocatalysis.Nature communications · 2026Article
- Functional characterization of a novel β-glucosidase converting trillin to diosgenin from Enterococcus faecalis.Microbial cell factories · 2026Article
- Direct synthesis of molecularly imprinted nanozymes with a biomimetic catalytic motif for glycosidic bond cleavage.Frontiers in chemistry · 2026Article
- Prospects and problems in enzyme immobilization methodology: comprehensive review.Biophysical reviews · 2025Review
- Cationic alkyl chain length and nanoaggregate form of ionic liquids dominate biocompatibility and toxicity.Nature communications · 2025Article
- Unlocking the full compositional control of hydrophilic and hydrophobic deep eutectic solvents over protein structure and stability.Communications chemistry · 2025Article
- Engineering enzyme conformation within liquid-solid hybrid microreactors for enhanced continuous-flow biocatalysis.Nature communications · 2024Article
- Stabilization of Non-Native Folds and Programmable Protein Gelation in Compositionally Designed Deep Eutectic Solvents.ACS nano · 2024Article
- Re-assessing viologens for modern bio-electrocatalysis.Chemical science · 2024Article
- Thermally Robust Solvent-Free Liquid Polyplexes for Heat-Shock Protection and Long-Term Room Temperature Storage of Therapeutic Nucleic Acids.Biomacromolecules · 2024Article
- Enzyme immobilization on covalent organic framework supports.Nature protocols · 2023Review
- Article
- Hydration in Deep Eutectic Solvents Induces Non-monotonic Changes in the Conformation and Stability of Proteins.Journal of the American Chemical Society · 2022Article
- Synergistic Hydrolysis of Cellulose by a Blend of Cellulase-Mimicking Polymeric Nanoparticle Catalysts.Journal of the American Chemical Society · 2022Article
- Chemical modification for improving catalytic performance of lipase B from Candida antarctica with hydrophobic proline ionic liquid.Bioprocess and biosystems engineering · 2022Article
- Boosted activity by engineering the enzyme microenvironment in cascade reaction: A molecular understanding.Synthetic and systems biotechnology · 2021Article
- Applications of Ionic Liquids in Whole-Cell and Isolated Enzyme Biocatalysis.Molecules (Basel, Switzerland) · 2021Review
- Article
- Single Enzyme Nanoparticles with Improved Biocatalytic Activity through Protein Entrapment in a Surfactant Shell.Biomacromolecules · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The increasing requirement to produce platform chemicals and fuels from renewable sources means advances in biocatalysis are rapidly becoming a necessity. Biomass is widely used in nature as a source of energy and as chemical building blocks. However, recalcitrance towards traditional chemical processes and solvents provides a significant barrier to widespread utility. Here, by optimizing enzyme solubility in ionic liquids, we have discovered solvent-induced substrate promiscuity of glucosidase, demonstrating an unprecedented example of homogeneous enzyme bioprocessing of cellulose. Specifically, chemical modification of glucosidase for solubilization in ionic liquids can increase thermal stability to up to 137 °C, allowing for enzymatic activity 30 times greater than is possible in aqueous media. These results establish that through a synergistic combination of chemical biology (enzyme modification) and reaction engineering (solvent choice), the biocatalytic capability of enzymes can be intensified: a key step towards the full-scale deployment of industrial biocatalysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.