Evidence map›Paper›PMID 29941858›Full record

ReviewGenes2018

The Role of aDNA in Understanding the Coevolutionary Patterns of Human Sexually Transmitted Infections.

Ville N Pimenoff, Charlotte J Houldcroft, Riaan F Rifkin, Simon Underdown

Open access · goldAbstract readReview
In one paragraph

Review in Genes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 4 countries.

Ville N PimenoffDepartment of Cancer Epidemiology and Prevention, Bellvitge Institute of Biomedical Research, Catalan Institute of Oncology, 08908 Barcelona, Spain. vnpimenoff@iconcologia.net.
Charlotte J HouldcroftDepartment of Medicine, Addenbrookes Hospital, University of Cambridge, Cambridge CB2 0QQ, UK. ch504@cam.ac.uk.ORCID 0000-0002-1833-5285
Riaan F RifkinCentre for Microbial Ecology and Genomics, Department of Biochemistry, Genetics and Microbiology, University of Pretoria, Hatfield 0028, South Africa. riaanrifkin@gmail.com.
Simon UnderdownHuman Origins and Palaeo-Environments Research Group, Department of Anthropology and Geography, Oxford Brookes University, Oxford OX3 0BP, UK. sunderdown@brookes.ac.uk.ORCID 0000-0001-6056-2353
Oxford Brookes University · GBUniversity of Cambridge · GBUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Analysis of pathogen genome data sequenced from clinical and historical samples has made it possible to perform phylogenetic analyses of sexually transmitted infections on a global scale, and to estimate the diversity, distribution, and coevolutionary host relationships of these pathogens, providing insights into pathogen emergence and disease prevention. Deep-sequenced pathogen genomes from clinical studies and ancient samples yield estimates of within-host and between-host evolutionary rates and provide data on changes in pathogen genomic stability and evolutionary responses. Here we examine three groups of pathogens transmitted mainly through sexual contact between modern humans to provide insight into ancient human behavior and history with their pathogens. Exploring ancient pathogen genomic divergence and the ancient viral-host parallel evolutionary histories will help us to reconstruct the origin of present-day geographical distribution and diversity of clinical pathogen infections, and will hopefully allow us to foresee possible environmentally induced pathogen evolutionary responses. Lastly, we emphasize that ancient pathogen DNA research should be combined with modern clinical pathogen data, and be equitable and provide advantages for all researchers worldwide, e.g., through shared data.

Indexed as

divergenceectoparasitesevolutionary medicineherpesvirusesHominin evolutionhost-switchpapillomavirusessexually transmitted infectionsvirus-host coevolution

Identifiers

PMID29941858
PMCPMC6070984
OpenAlexW2810481348

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.