SynthesisNutrients2018
What Is the Role of Nutritional Supplements in Support of Total Hip Replacement and Total Knee Replacement Surgeries? A Systematic Review.
Synthesis in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03793036 (A Randomized Controlled Study of Preoperative Oral Carbohydrate Loading Versus Fasting in Patients Undergoing Colorectal Surgery), which is not on this map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Controlled Study of Preoperative Oral Carbohydrate Loading Versus Fasting in Patients Undergoing Colorectal Surgery
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Effects of amino acid supplementation on muscle mass, muscle performance and functional capacity in subjects undergoing total knee arthroplasty: a systematic review of randomized clinical trials.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2024Pooled it
- Role of nutritional supplements on oral health in adults - A systematic review.F1000Research · 2023Pooled it
- A randomised controlled study of preoperative oral carbohydrate loading versus fasting in patients undergoing colorectal surgery.International journal of colorectal disease · 2019Trial
- Glutamine metabolism in health and disease.Signal transduction and targeted therapy · 2026Review
- Effect of a Milk Protein Concentrate Supplement on Muscle Recovery and Oxidative Stress Following Knee and Hip Arthroplasty: A Randomized Control Trial.Antioxidants (Basel, Switzerland) · 2026Article
- Article
- The Effect of Video-Based Education on Activities of Daily Living and Wound Healing of Patients with Total Hip Replacement: Randomised Controlled Trials.Nursing reports (Pavia, Italy) · 2025Article
- Nutritional Assessment and Management of Patients with Brain Neoplasms Undergoing Neurosurgery: A Systematic Review.Cancers · 2025Review
- Accelerating Recovery: A Case Report on Telerehabilitation for a Triathlete's Post-Meniscus Surgery Comeback.Healthcare (Basel, Switzerland) · 2025Article
- Adoption and acceptability of a perioperative nutrition program among total joint arthroplasty patients.Frontiers in health services · 2025Article
- The dynamics of perioperative serum albumin before and after total knee arthroplasty.Journal of orthopaedics · 2024Article
- Improved outcomes with perioperative dietitian-led interventions in patients undergoing total joint arthroplasty: A systematic review.Journal of orthopaedics · 2024Review
- Preoperative low serum albumin increases the rate of perioperative blood transfusion in patients undergoing total joint arthroplasty: propensity score matching.BMC musculoskeletal disorders · 2024Article
- Review
- Post-operative protein supplementation following orthopaedic surgery: A systematic review.Sports medicine and health science · 2024Review
- A Pilot Study of Nutritional Supplementation in Soft Tissue Sarcoma Patients.The Iowa orthopaedic journal · 2023Article
- Why malnutrition in orthopaedic elective patient is still an issue? A recent review of the literature.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2023Review
- Immunonutrition in Orthopedic and Traumatic Patients.Nutrients · 2023Review
- Healthy Eating for Elective Major Orthopedic Surgery: Quality, Quantity, and Timing.Journal of multidisciplinary healthcare · 2023Article
- Preoperative High Sleep Quality Predicts Further Decrease in Length of Stay after Total Joint Arthroplasty under Enhanced Recovery Short-stay Program: Experience in 604 Patients from a Single Team.Orthopaedic surgery · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nutritional supplements can influence outcomes for individuals undergoing major surgery, particularly in older persons whose functional reserve is limited. Accelerating recovery from total hip replacement (THR) and total knee replacement (TKR) may offer significant benefits. Therefore, we explored the role of nutritional supplements in improving recovery following THR and TKR. A systematic review was conducted to source randomized clinical trials that tested nutritional supplements in cohorts of THR or TKR patients. Our search yielded nine relevant trials. Intake of a carbohydrate-containing fluid is reported to improve insulin-like growth factor levels, reduce hunger, nausea, and length of stay, and attenuate the decrease in whole-body insulin sensitivity and endogenous glucose release. Amino acid supplementation is reported to reduce muscle atrophy and accelerate return of functional mobility. One paper reported a suppressive effect of beta-hydroxy beta-methylbutyrate, L-arginine, and L-glutamine supplementation on muscle strength loss following TKR. There is limited evidence for nutritional supplementation in THR and TKR pathways; however, the low risk profile and potential benefits to adjunctive treatment methods, such as exercise programs, suggest nutritional supplements may have a role. Optimizing nutritional status pre-operatively may help manage the surgical stress response, with a particular benefit for undernourished, frail, or elderly individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.