ReviewInternational journal of molecular sciences2018
Molecular Mechanisms for Regulating Postnatal Ductus Arteriosus Closure.
Review in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Regional oxygen saturation as a non-invasive indicator for neonatal PDA: a systematic review and meta-analysis.BMC pediatrics · 2026Pooled it
- The relationship between platelet indices and patent ductus arteriosus in preterm infants: a systematic review and meta-analysis.European journal of pediatrics · 2021Pooled it
- Porcine versus bovine surfactant therapy for RDS in preterm neonates: pragmatic meta-analysis and review of physiopathological plausibility of the effects on extra-pulmonary outcomes.Respiratory research · 2020Pooled it
- Spontaneous Closure of the Ductus Arteriosus in Preterm Infants: A Systematic Review.Frontiers in pediatrics · 2020Pooled it
- Inflammatory Indices in Preterm Infants with Hemodynamically Significant Patent Ductus Arteriosus: Early Postnatal Patterns and Treatment Response.Children (Basel, Switzerland) · 2026Article
- Prevalence of Cardiovascular Functional Anomalies in Large-for-Gestational-Age (LGA) Fetuses by Fetal Echocardiography.Journal of clinical medicine · 2025Article
- Prenatal Diagnosis of Ductal Constriction in Normal Heart Anatomy-Are There Any Neonatal Consequences?Journal of clinical medicine · 2025Article
- Serum Biomarkers in Patent Ductus Arteriosus in Preterm Infants: A Narrative Review.Biomedicines · 2025Review
- Keeping the Ductus Arteriosus Patent: Current Strategy and Perspectives.Diagnostics (Basel, Switzerland) · 2025Review
- Article
- Hereditary TTP/Upshaw-Schulman syndrome: the ductus arteriosus controls newborn survival.International journal of hematology · 2024Review
- Identification and Functional Verification of CITED2 Gene Promoter Region in Patients with Patent Ductus Arteriosus.International journal of molecular sciences · 2023Article
- Article
- Echocardiographic assessment of intimal thickness growth of patent ductus arteriosus in neonates and analysis of influencing factors.The international journal of cardiovascular imaging · 2022Article
- Transcriptional Evaluation of the Ductus Arteriosus at the Single-Cell Level Uncovers a Requirement for Vim (Vimentin) for Complete Closure.Arteriosclerosis, thrombosis, and vascular biology · 2022Article
- Potassium Channels in the Transition from Fetal to the Neonatal Pulmonary Circulation.International journal of molecular sciences · 2022Article
- An Update on Patent Ductus Arteriosus and What is Coming Next.Turkish archives of pediatrics · 2022Article
- Specialized Pro-Resolving Lipid Mediators in Neonatal Cardiovascular Physiology and Diseases.Antioxidants (Basel, Switzerland) · 2021Review
- Cinaciguat Prevents Postnatal Closure of Ductus Arteriosus by Vasodilation and Anti-remodeling in Neonatal Rats.Frontiers in physiology · 2021Article
- Severing umbilical ties.eLife · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ductus arteriosus (DA) connects the main pulmonary artery and the aorta in fetal circulation and closes spontaneously within days after birth in normal infants. Abnormal patent DA (PDA) causes morbidities and mortality, especially in preterm infants. Closure of the DA is a complex interactive process involving two events: functional and anatomic closure. Functional closure by smooth muscle contraction was achieved through the regulatory factors of vaso-reactivity. These factors include oxygen sensing system, glutamate, osmolality, prostaglandin E₂, nitric oxide, and carbon monoxide. Anatomic closure by vascular remodeling involved several vascular components including endothelium, extracellular matrix, smooth muscle cells, and intraluminal blood cells. Despite advances in understanding of PDA pathogenesis, the molecular mechanism for regulation of DA closure is complex and not fully understood. In this article we review recent evidence regarding the molecular mechanisms of DA closure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.