ArticleChinese medical journal2018
Genistein Improves Liver Damage in Male Mice Exposed to Morphine.
Article in Chinese medical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 47 citations in OpenAlex.
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- Ameliorative Effect of Rice Husk Methanol Extract on Liver and Kidney Toxicities Induced by Subchronic Codeine Administration.International journal of food science · 2023Article
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- Royal jelly protects dichlorvos liver-induced injury in male Wistar rats.Research in pharmaceutical sciences · 2022Article
- The effect of Crocin on sperm parameters disorders induced by peripheral administration of nitrosamines in male rats.Journal of medicine and life · 2022Article
- Protective effect of isoflavones and triterpenoid saponins from pueraria lobata on liver diseases: A review.Food science & nutrition · 2022Review
- Detoxification technology and mechanism of processing withFrontiers in pharmacology · 2022Article
- Evaluation of biomarkers in liver followingJournal of diabetes and metabolic disorders · 2020Article
- Anti-inflammatory, anti-apoptotic, and antioxidant actions of Middle Eastern Phoenix dactylifera extract on mercury-induced hepatotoxicity in vivo.Molecular biology reports · 2020Article
- Genistein improve nicotine toxicity on male mice pancreas.Anatomy & cell biology · 2019Article
- Effect of pentoxifylline on kidney damage induced by nitrosamine in male rats.Research in pharmaceutical sciences · 2019Article
- Effects of Crocin on Sperm Parameters and Seminiferous Tubules in Diabetic Rats.Advanced biomedical research · 2019Article
- Effect of Falcaria Vulgaris on Milk Production Parameters in Female Rats' Mammary Glands.Journal of family & reproductive health · 2018Article
- Corrigendum: Genistein Improves Liver Damage in Male Mice Exposed to Morphine.Chinese medical journal · 2018Article
- Improvement ofInternational journal of applied & basic medical researchArticle
- Resveratrol attenuates malathion-induced liver damage by reducing oxidative stress.Journal of laboratory physiciansArticle
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMorphine is commonly used to treat severe pain. This substance is significantly metabolized in the liver and causes disturbing effects. Genistein is an isoflavone and has antioxidant properties. The aim of this study was to evaluate the effects of genistein against morphine damages on mouse liver.
methodsBetween May 2017 and March 2018, 48 male mice were divided into six groups (n = 8 in each group). Various doses of genistein (25 and 50 mg/kg) and morphine plus genistein (25 and 50 mg/kg) were administered intraperitoneally to 48 male mice for 20 consequent days. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), serum nitric oxide (NO) levels, liver weight, and the diameter of hepatocytes and central hepatic vein were studied and compared using one-way analysis of variance.
resultsMorphine administration significantly increased the mean diameter of the central hepatic vein (22.76 ± 1.9 μm vs. 15.04 ± 0.60 μm, χ
conclusionIt seems that genistein administration might improve liver damages induced by morphine in mice.
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