Evidence map›Paper›PMID 29941705›Full record

ArticleChinese medical journal2018

Increased Macroautophagy in Interferon-Gamma-Producing T Cells from Patients with Newly Diagnosed Systemic Lupus Erythematosus.

Xiong-Yan Luo, Jia-Li Yuan, Jing Liu, Cai-Nan Luo, Ming-Hui Yang, Qin Wei, Min Yang, Yong Chen, Yi Liu, Guo-Hua Yuan

Open access · goldAbstract read
In one paragraph

Article in Chinese medical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Hypomethylation ofAnnals of the rheumatic diseases · 2019
    Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Xiong-Yan LuoDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Jia-Li YuanDepartment of Rheumatology, The First People's Hospital of Jian Yang City, Chengdu, Sichuan 641400, China.
Jing LiuInstitute of Rheumatology and Immunology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 63700, China.
Cai-Nan LuoDepartment of Rheumatology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang 830000, China.
Ming-Hui YangInstitute of Rheumatology and Immunology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 63700, China.
Qin WeiDepartment of Rheumatology, The First People's Hospital of Xinxiang, Xinxiang Medical University, Xinxiang, Henan 453000, China.
Min YangDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Yong ChenDepartment of Rheumatology, The First People's Hospital of Jian Yang City, Chengdu, Sichuan 641400, China.
Yi LiuDepartment of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
Guo-Hua YuanInstitute of Rheumatology and Immunology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan 63700, China.
Affiliated Hospital of North Sichuan Medical College · CNSichuan University · CNPeople's Hospital of Xinjiang Uygur Autonomous Region · CNWest China Hospital of Sichuan University · CNXinxiang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImbalance of interferon-gamma (IFN-γ), interleukin (IL)-4, and IL-17 producing by T cells is confirmed to contribute to the pathogenesis of systemic lupus erythematosus (SLE). Autophagy is now emerging as a core player in the development and the function of the immune system. Therefore, we investigated the autophagic behavior in IFN-γ-, IL-4-, and IL-17-producing T cells from patients with SLE.

methodsThirty patients with SLE and 25 healthy controls matched for gender and age were recruited between September 2016 and May 2017. The autophagic levels in IFN-γ

resultsOur results showed increased percentage of autophagy in IFN-γ

conclusionThe results indicate that autophagy in IFN-γ

Indexed as

AutophagyAdultChinaFemaleHumansInterferon-gammaInterleukin-17Interleukin-4Lupus Erythematosus, SystemicMaleMiddle AgedTh1 CellsInterferon-gammaInterleukin-17Interleukin-4AutophagyLupus ErythematosusSystemicT Helper cells

Identifiers

PMID29941705
PMCPMC6032673
OpenAlexW2811276453

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.