ArticleOccupational and environmental medicine2018
Study of occupation and amyotrophic lateral sclerosis in a Danish cohort.
Article in Occupational and environmental medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Military service and related risk factors for amyotrophic lateral sclerosis.Acta neurologica Scandinavica · 2021Pooled it
- Military Service Roles and ALS Among Veterans: A Matched Case-Control Study.Annals of clinical and translational neurology · 2025Article
- Clinical and Sociodemographic Factors Related to Amyotrophic Lateral Sclerosis in Spain: A Pilot Study.Journal of clinical medicine · 2024Article
- Medication use and risk of amyotrophic lateral sclerosis: using machine learning for an exposome-wide screen of a large clinical database.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2024Article
- Role of the Exposome in Neurodegenerative Disease: Recent Insights and Future Directions.Annals of neurology · 2024Review
- Occupational history associates with ALS survival and onset segment.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2023Article
- Long-term Traffic-related Air Pollutant Exposure and Amyotrophic Lateral Sclerosis Diagnosis in Denmark: A Bayesian Hierarchical Analysis.Epidemiology (Cambridge, Mass.) · 2022Article
- New evidence on the association of occupation with amyotrophic lateral sclerosis: A register-based case-control study in Finland.Frontiers in neurology · 2022Article
- Joint and interactive effects between health comorbidities and environmental exposures in predicting amyotrophic lateral sclerosis.International journal of hygiene and environmental health · 2021Article
- Risk factors for amyotrophic lateral sclerosis: A regional United States case-control study.Muscle & nerve · 2021Article
- Atypical motor neuron disease with bent spine clinical onset and long survival carrying C9orf72 expansion.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Study of Occupational Chromium, Iron, and Nickel Exposure and Amyotrophic Lateral Sclerosis in Denmark.International journal of environmental research and public health · 2020Article
- Reply to Comment on "Environmental and Occupational Risk Factors of Amyotrophic Lateral Sclerosis: A Population-Based Case-Control Study".International journal of environmental research and public health · 2020Article
- Comment on: Filippini, T.; Tesauro, M.; Fiore, M.; Malagoli, C.; Consonni, M.; Violi, F.; Iacuzio, L.; Arcolin, E.; Oliveri Conti, G.; Cristaldi, A.; Zuccarello, P.; Zucchi, E.; Mazzini, L.; Pisano, F.; Gagliardi, I.; Patti, F.; Mandrioli, J.; Ferrante, M.; Vinceti, M. Environmental and Occupational Risk Factors of Amyotrophic Lateral Sclerosis: A Population-Based Case-Control Study.International journal of environmental research and public health · 2020Article
- A mixtures approach to solvent exposures and amyotrophic lateral sclerosis: a population-based study in Denmark.European journal of epidemiology · 2020Article
- The use of Logic regression in epidemiologic studies to investigate multiple binary exposures: an example of occupation history and amyotrophic lateral sclerosis.Epidemiologic methods · 2020Article
- Epidemiology of amyotrophic lateral sclerosis: an update of recent literature.Current opinion in neurology · 2019Review
- Population-based study of amyotrophic lateral sclerosis and occupational lead exposure in Denmark.Occupational and environmental medicine · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectivesSeveral manuscripts have proposed associations between amyotrophic lateral sclerosis (ALS) and occupational toxicant exposures-not to mention physical activity and trauma/injury. Some have also reported associations in investigations of specific occupations. Using data from a prospective Danish cohort study, we investigated the association between employment in certain industries and ALS diagnosis.
methodsWe identified 1826 ALS cases who were 25 years old or less in 1964 and diagnosed from 1982 to 2013 from the Danish National Patient Registry then matched 100 population controls to each case based on birth year and sex. Demographic data were linked to the Danish Pension Fund to determine occupation history. Conditional logistic regression models were adjusted for socioeconomic status, marital status and residential location at the index date.
resultsThere was an increase in odds of ALS among men who worked in agriculture, hunting, forestry or fishing (adjusted OR (aOR)=1.21; 95% CI 1.02 to 1.45). There was also a positive association for men employed in construction (aOR=1.21; 95% CI 1.05 to 1.39). In women, a protective association was seen with employment in the cleaning industry (aOR=0.69; 95% CI 0.52 to 0.93).
conclusionsOur study shows various occupations with exposure to toxicants, such as diesel exhaust and lead, and strenuous physical activity associated with increased odds of ALS in men. Future studies should have a particular focus on gathering detailed information on physical exertion and toxicant exposures specific to certain job tasks.
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