Evidence map›Paper›PMID 29941636›Full record

ArticleAntimicrobial agents and chemotherapy2018

Validating a 14-Drug Microtiter Plate Containing Bedaquiline and Delamanid for Large-Scale Research Susceptibility Testing of Mycobacterium tuberculosis.

Paola M V Rancoita, Federica Cugnata, Ana Luíza Gibertoni Cruz, Emanuele Borroni, Sarah J Hoosdally, Timothy M Walker, Clara Grazian, Timothy J Davies, Timothy E A Peto, Derrick W Crook and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Antimicrobial agents and chemotherapy · 2025
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  12. Drug-Resistant Profiles and Genetic Diversity ofInfection and drug resistance · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Paola M V Rancoita *University Centre of Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan, Italy.
Federica Cugnata *University Centre of Statistics in the Biomedical Sciences, Vita-Salute San Raffaele University, Milan, Italy.
Ana Luíza Gibertoni Cruz *Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Headley Way, Oxford, United Kingdom.
Emanuele BorroniEmerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Sarah J HoosdallyNuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Headley Way, Oxford, United Kingdom.
Timothy M WalkerNuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Headley Way, Oxford, United Kingdom.
Clara GrazianNuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Headley Way, Oxford, United Kingdom.
Timothy J DaviesNuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Headley Way, Oxford, United Kingdom.
Timothy E A PetoNuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Headley Way, Oxford, United Kingdom.
Derrick W CrookNuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Headley Way, Oxford, United Kingdom.
Philip W Fowler *Nuffield Department of Medicine, John Radcliffe Hospital, University of Oxford, Headley Way, Oxford, United Kingdom.ORCID 0000-0003-0912-4483
Daniela M Cirillo *Emerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy cirillo.daniela@hsr.it.ORCID 0000-0001-6415-1535
CRyPTIC Consortiumfor the CRyPTIC Consortiumfor the CRyPTIC Consortium
John Radcliffe Hospital · GBVita-Salute San Raffaele University · IT

Funding

Department of HealthMedical Research Council MC_PC_16027Wellcome TrustWellcome Trust 200205/Z/15/Z
6 · The paper itself

Abstract

The UKMYC5 plate is a 96-well microtiter plate designed by the CRyPTIC Consortium (Comprehensive Resistance Prediction for Tuberculosis: an International Consortium) to enable the measurement of MICs of 14 different antituberculosis (anti-TB) compounds for >30,000 clinical

Indexed as

Antitubercular AgentsClofazimineDiarylquinolinesDrug Resistance, Multiple, BacterialHumansLinezolidMicrobial Sensitivity TestsMycobacterium tuberculosisNitroimidazolesOxazolesReproducibility of ResultsTuberculosisTuberculosis, Multidrug-ResistantAntitubercular AgentsbedaquilineClofazimineDiarylquinolinesLinezolidNitroimidazolesOPC-67683Oxazolesantibiotic resistanceantimicrobial agentsdiagnosticsMycobacterium tuberculosis

Identifiers

PMID29941636
PMCPMC6125532
OpenAlexW2949464256

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.